TMEM59 - transmembrane protein 59 Gene

Also Known as DCF1; C1orf8; PRO195; UNQ169; HSPC001

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9528

About TMEM59

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:54,026,681-54,053,573 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 47.8), prostate (RPKM 39.1) and 25 other tissues.

Summary

This gene encodes a protein shown to regulate Autophagy in response to Bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote Apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEM59 Products (7)

mRNA Protein Name
NM_001305043.2 NP_001291972.1 transmembrane protein 59 isoform 1 precursor
NM_001305049.1 NP_001291978.1 transmembrane protein 59 isoform 3 precursor
NM_001305050.2 NP_001291979.1 transmembrane protein 59 isoform 4 precursor
NM_001305051.1 NP_001291980.1 transmembrane protein 59 isoform 6 precursor
NM_001305052.1 NP_001291981.1 transmembrane protein 59 isoform 6 precursor
NM_001305066.2 NP_001291995.1 transmembrane protein 59 isoform 5 precursor
NM_004872.5 NP_004863.2 transmembrane protein 59 isoform 2 precursor

TMEM59 Protein Structure

BSMAP

BSMAP: Brain specific membrane anchored protein (72 - 256)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

transmembrane protein 59

  • dendritic cell factor 1

TMEM59 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM59 Q9BXS4 ATG16L1 Homo sapiens Q676U5
Pull Down
23376921
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Estrogen Resistance

  • Estrogen Resistance Syndrome

  • ESTRR

  • Estrogen Insensitivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14731 TMEM59 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM59 VGNC VGNC:47590
Rattus norvegicus TMEM59 RGD RGD:1310313
Macaca mulatta TMEM59 VGNC VGNC:78665
Mus musculus TMEM59 MGD MGI:1929278
Bos taurus TMEM59 VGNC VGNC:36099
Others TMEM59 NCBI