country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

ATG12 - autophagy related 12 Gene

Also Known as APG12; FBR93; APG12L; HAPG12

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9140

About ATG12

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,828,200-115,841,565 (from NCBI)

This gene has 13 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in brain (RPKM 8.9), fat (RPKM 8.2) and 25 other tissues.

Summary

Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in Autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]

ATG12 Products (2)

mRNA	Protein	Name
NM_001277783.2	NP_001264712.1	ubiquitin-like protein ATG12 isoform 2
NM_004707.4	NP_004698.3	ubiquitin-like protein ATG12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9852036	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	25484072	GOA
involved in negative regulation of defense response to virus	IDA IDA: Inferred from direct assay	19666601	GOA
involved in positive regulation of viral translation	IDA IDA: Inferred from direct assay	19666601	GOA
involved in regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	22342342	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Atg12-Atg5-Atg16 complex	IPI IPI: Inferred from physical interaction	23202584	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	24954904	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG12 Protein Structure

APG12

0
100
140 a.a.

Protein Preferred Names	Protein Names
ubiquitin-like protein ATG12	APG12 autophagy 12-like

ATG12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATG12	O94817	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ATG12	O94817	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ATG12	O94817	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ATG12	O94817	IER2	Homo sapiens	Q9BTL4	Y2H Array	32296183
Intra	ATG12	O94817	IER2	Homo sapiens	Q9BTL4	Y2H Prey Pooling	32296183
Intra	ATG12	O94817	IER2	Homo sapiens	Q9BTL4	Validated Y2H	32296183
Intra	ATG12	O94817	SERTAD2	Homo sapiens	Q14140	Y2H Array	32296183
Intra	ATG12	O94817	SERTAD2	Homo sapiens	Q14140	Y2H Prey Pooling	32296183
Intra	ATG12	O94817	SERTAD2	Homo sapiens	Q14140	Validated Y2H	32296183
Intra	ATG12	O94817	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	ATG12	O94817	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	ATG12	O94817	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
Intra	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Y2H Prey Pooling	32296183
Intra	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	35271311
Intra	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Validated Y2H	32296183
Intra	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	ITC	23202584
Intra	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	20562859
Intra	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Y2H Array	32296183
Intra	ATG12	O94817	ATG3	Homo sapiens	Q9NT62	Anti Bait CoIP	17353931

Cross: Cross-species interaction Intra: Intraspecies interaction

ATG12 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80021	Atg12 Antibody (YA830)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86775	ATG12 Antibody (YA6468)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Stomatitis
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Mouth Disease	Mouth Diseases Mouth Disorders
Macular Degeneration, Age-Related, 14	Age Related Macular Degeneration 14 ARMD14 Macular Degeneration, Age-Related, 14, Reduced Risk Of Macular Degeneration, Age-Related, Type 14
Acute Laryngopharyngitis	Pharyngolaryngitis Laryngopharyngitis Hypopharyngitis
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0538	Xylitol		99.5%	Yes

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156966	ATG12-ATG3 inhibitor 1	Inhibitor	98.19%	Unkown
HY-162932	ATG12-IN-1	Inhibitor	/	Unkown
HY-183826	ATG5 PPI-IN-4	Inhibitor	/	Unkown
HY-RS01140	ATG12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W768347	Xylitol-13C5		/	Unkown
HY-RS21488	Atg12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28006	Atg12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATG12	VGNC	VGNC:67741
Mus musculus	ATG12	MGD	MGI:1914776
Canis familiaris	ATG12	VGNC	VGNC:38216
Macaca mulatta	ATG12	VGNC	VGNC:110488
Rattus norvegicus	ATG12	RGD	RGD:1306306
Bos taurus	ATG12	VGNC	VGNC:26250
Others	ATG12	NCBI