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Cat. No.: HY-162932

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ATG12-IN-1

ATG12-IN-1 (compound 4) is an autophagy inhibitor (IC₅₀=9 μM) targeting the ATG12-ATG3 protein-protein interaction, which can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2950162-68-0
Formula: C₂₃H₁₅ClN₄O₂
Molecular Weight:414.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

ATG12-IN-1 Chemical Structure

CAS No.: 2950162-68-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

ATG12-IN-1 (compound 4) is an autophagy inhibitor (IC₅₀=9 μM) targeting the ATG12-ATG3 protein-protein interaction, which can be used in cancer research^[1].

Chemical Information

CAS No. 2950162-68-0
Molecular Weight 414.84
Formula C₂₃H₁₅ClN₄O₂
SMILES

OC(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)N4C2=NC(C5=CC=CC=C5)=C4)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Skach K, et al. Structure–activity relationship study of small-molecule inhibitor of Atg12-Atg3 protein–protein interaction[J]. Bioorganic & Medicinal Chemistry Letters, 2024, 112: 129939. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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