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Cat. No.: HY-183826

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ATG5 PPI-IN-4

ATG5 PPI-IN-4 is an autophagy inhibitor targeting ATG5, with an IC₅₀ of 12.78 μM against ATG5-ATG16L1 and an IC₅₀ of 12.00 μM against ATG5-TECAIR. ATG5 PPI-IN-4 blocks the protein interactions between ATG5 and ATG16L1, as well as between ATG5 and TECAIR, disrupts the assembly of the ATG12-ATG5-ATG16L1 ternary complex, inhibits the lipidation modification of LC3/ATG8, and ultimately downregulates cellular autophagy levels. ATG5 PPI-IN-4 can be used in autophagy-related research, such as studies on infection and cancer.

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CAS No.: 2841473-91-2
Formule: C₃₁H₂₄N₂O₅
Masse moléculaire:504.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

ATG5 PPI-IN-4 Chemical Structure

CAS No.: 2841473-91-2

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Activité biologique

Description

In Vitro

ATG5 PPI-IN-4 (compound 17c) inhibits the ATG5-ATG16L1 interaction (IC₅₀ = 12.78 μM) and ATG5-TECAIR interaction (IC₅₀ = 12.00 μM) in cell-free HTRF in vitro binding assay^[1].
ATG5 PPI-IN-4 (20 μM; 6 h) reduces autophagy incidence in HBSS-induced autophagy model of COS-7 cells based on flow cytometry detection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2841473-91-2
Masse moléculaire 504.53
Formule C₃₁H₂₄N₂O₅
SMILES

CC(NC(C=C1)=CC=C1C2=CC=C(O2)/C=C(C3=O)\C=C(C4=CC=CC=C4)N3CC5=CC=C(C=C5)C(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Xiang H, et al. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein–Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 7;66(4):2457-2476.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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