2841473-91-2
Chemical Structure
ATG5 PPI-IN-4
- CAS No.: 2841473-91-2
- Formula:C31H24N2O5
- Molecular Weight:504.53
InChIKey: ZNRYJMCRATXZRQ-KOEQRZSOSA-N
SMILES: CC(NC(C=C1)=CC=C1C2=CC=C(O2)/C=C(C3=O)\C=C(C4=CC=CC=C4)N3CC5=CC=C(C=C5)C(O)=O)=O
Biological Activity:
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ATG5 PPI-IN-4 | ATG5 PPI-IN-4 is an autophagy inhibitor targeting ATG5, with an IC50 of 12.78 μM against ATG5-ATG16L1 and an IC50 of 12.00 μM against ATG5-TECAIR. ATG5 PPI-IN-4 blocks the protein interactions between ATG5 and ATG16L1, as well as between ATG5 and TECAIR, disrupts the assembly of the ATG12-ATG5-ATG16L1 ternary complex, inhibits the lipidation modification of LC3/ATG8, and ultimately downregulates cellular autophagy levels. ATG5 PPI-IN-4 can be used in autophagy-related research, such as studies on infection and cancer. |
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