IER2 - immediate early response 2 Gene

Also Known as CHX1; ETR101

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9592

About IER2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:13,150,411-13,154,911 (from NCBI)

This gene has 3 transcripts (splice variants), 160 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 98.0), bone marrow (RPKM 95.1) and 24 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in cell motility and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

IER2 Products (1)

mRNA Protein Name
NM_004907.3 NP_004898.2 immediate early response gene 2 protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cell motility IMP
IMP: Inferred from mutant phenotype
22120713 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19584537 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22120713 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22120713 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IER2 Protein Structure

IER

IER: Immediate early response protein (IER) (1 - 102)

IER

IER: Immediate early response protein (IER) (100 - 223)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

immediate early response gene 2 protein

  • chxI protein homolog

IER2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IER2 Q9BTL4 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
IER2 Q9BTL4 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

  • Asphyxiating Thoracic Dystrophy 4

  • SRTD4

  • Atd4

  • Jatd

  • Jeune Asphyxiating Thoracic Dystrophy

  • Jeune Syndrome 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06547 IER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IER2 VGNC VGNC:62871
Bos taurus IER2 VGNC VGNC:30038
Canis familiaris IER2 VGNC VGNC:41868
Mus musculus IER2 MGD MGI:104815
Rattus norvegicus IER2 RGD RGD:1359581
Others IER2 NCBI