4E1RCat 17d
4E1RCat 17d is a derivative of the ATG5 inhibitor lead compound T1742 (HY-183807). 4E1RCat 17d shows no activity against the interactions of ATG5-ATG16L1 and ATG5-TECAIR. 4E1RCat 17d induces Autophagy inhibition.
For research use only. We do not sell to patients.
- CAS No.: 2841473-92-3
- Formula: C31H24N2O5
- Molecular Weight:504.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
4E1RCat 17d (Compound 17d) shows no obvious inhibitory activity against the ATG5−ATG16L1 and ATG5−TECAIR interactions in a cell-free HTRF binding assay[1].
4E1RCat 17d (20 μM; 6 h) inhibits autophagy in COS-7 cells, reducing autophagy incidence to 20.01%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:COS-7 cells
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Concentration:20 μM
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Incubation Time:6 h
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Result:Reduced autophagy incidence in COS-7 cells to 20.01%.
Chemical Information
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CAS No. 2841473-92-3
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Molecular Weight 504.53
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Formula C31H24N2O5
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SMILES
CC(NC1=CC=CC(C2=CC=C(O2)/C=C(C3=O)\C=C(C4=CC=CC=C4)N3CC5=CC=C(C=C5)C(O)=O)=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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