Autophagy-IN-11
Autophagy-IN-11 is an ATG5-targeting autophage inhibitor. Autophagy-IN-11 disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR. Autophagy-IN-11 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2841473-96-7
- Formula: C29H20N2O6
- Molecular Weight:492.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Autophagy-IN-11 (Compound 17g) inhibits ATG5-ATG16L1 interactions with an IC50 of 6.14 μM and ATG5-TECAIR interactions with an IC50 of 10.47 μM in a purified protein HTRF binding assay[1].
Autophagy-IN-11 (20 μM; 6 h) reduces autophagy incidence to 36.05% in HBSS-induced COS-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:COS-7 cells
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Concentration:20 μM
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Incubation Time:6 h
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Result:Reduced autophagy incidence to 36.05% in HBSS-induced COS-7 cells, compared to control autophagy induction levels.
Chemical Information
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CAS No. 2841473-96-7
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Molecular Weight 492.48
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Formula C29H20N2O6
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SMILES
O=C(N(C(C1=CC=CC=C1)=C/2)CC3=CC=C(C=C3)C(O)=O)C2=C\C4=CC=C(C5=CC([N+]([O-])=O)=CC=C5)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Autophagy-IN-11 Related Classifications
HY-183838 Related Classifications
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