1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    Autophagy
    Anti-infection
  2. RAR/RXR
    SPHK
    Autophagy
    HCV
  3. Peretinoin

Peretinoin (Synonyms: NIK333)

Cat. No.: HY-100008 Purity: 98.38%
Handling Instructions

Peretinoin is an oral acyclic retinoid retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM.

For research use only. We do not sell to patients.

Peretinoin Chemical Structure

Peretinoin Chemical Structure

CAS No. : 81485-25-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 277 In-stock
Estimated Time of Arrival: December 31
5 mg USD 252 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1560 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Peretinoin is an oral acyclic retinoid retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].

IC50 & Target[1]

RAR

 

RXR

 

In Vitro

Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes[2].
Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed SPHK1 expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment [1].

Cell Autophagy Assay[2]

Cell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line
Concentration: 5 μM
Incubation Time: 24 hours
Result: Up-regulated the expression of LC3B-II and increased autophagy flux.

Western Blot Analysis[1]

Cell Line: Human hepatoma (Huh-7) cells
Concentration: 10, 20 and 40 μM
Incubation Time: 12, 24, 48 and 72  hours
Result: Exhibited suppressed SPHK1 expression after 24 h treatment, even at 10 μM.
Clinical Trial
Molecular Weight

302.45

Formula

C₂₀H₃₀O₂

CAS No.

81485-25-8

SMILES

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/C=C/C(C)=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (330.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3063 mL 16.5317 mL 33.0633 mL
5 mM 0.6613 mL 3.3063 mL 6.6127 mL
10 mM 0.3306 mL 1.6532 mL 3.3063 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Peretinoin
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