1. Anti-infection
  2. HCV

Peretinoin (Synonyms: NIK-333; NIK333; NIK 333)

Cat. No.: HY-100008 Purity: 98.21%
Data Sheet SDS Handling Instructions

Peretinoin is an oral acyclic retinoid, inhibits HCV RNA amplification and virus release by altering lipid metabolism.

For research use only. We do not sell to patients.
Peretinoin Chemical Structure

Peretinoin Chemical Structure

CAS No. : 81485-25-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $231 In-stock
5 mg $210 In-stock
10 mg $350 In-stock
50 mg $850 In-stock
100 mg $1300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Peretinoin is an oral acyclic retinoid, inhibits HCV RNA amplification and virus release by altering lipid metabolism. Target: HCV in vitro: Peretinoin is an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors, such as retinoid X receptor and retinoic acid receptor. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism. Peretinoin suppresses the RNA replication of H77S.3/GLuc2A most efficiently and its EC50 was 9 μM. Peretinoin may reduce the recurrence of hepatocellular carcinoma (HCC) following surgical ablation of primary tumours. Peretinoin inhibits RNA replication for all genotypes and showed the strongest antiviral effect among the retinoids tested. in vivo: In addition, Peretinoin prevents the development of hepatoma in several different hepatoma models.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01640808 Kowa Company, Ltd. Hepatic Neoplasm Malignant Recurrent April 2012 Phase 3
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References
M.Wt

302.45

Formula

C₂₀H₃₀O₂

CAS No.

81485-25-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 100 mg/mL;
In vivo: Peretinoin is dissolved in DMSO (3 mg/mL) and then diluted with water (DMSO: water=1:1).

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Peretinoin
Cat. No.:
HY-100008
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