ATG5 PPI-IN-6
ATG5 PPI-IN-6 is an inhibitor of ATG5 interactions with other proteins, with an IC50 value of 26.92 μM against ATG5-ATG16L1 and 16.34 μM against ATG5-TECAIR. ATG5 PPI-IN-6 inhibits Autophagy in cells.
For research use only. We do not sell to patients.
- CAS No.: 2841473-87-6
- Formula: C31H23NO5
- Molecular Weight:489.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ATG5 PPI-IN-6 (Compound 17a) (16.34-26.92 μM) inhibits the ATG5-ATG16L1 interaction with an IC50 of 26.92 μM and the ATG5-TECAIR interaction with an IC50 of 16.34 μM in an in vitro HTRF binding assay[1].
ATG5 PPI-IN-6 (20 μM; 6 h) reduces autophagy incidence in COS-7 cells to 14.61%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:COS-7 cells
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Concentration:20 μM
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Incubation Time:6 h
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Result:Reduced autophagy incidence in COS-7 cells to 14.61%.
Chemical Information
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CAS No. 2841473-87-6
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Molecular Weight 489.52
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Formula C31H23NO5
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SMILES
CC(C(C=C1)=CC=C1C2=CC=C(O2)/C=C(C3=O)\C=C(C4=CC=CC=C4)N3CC5=CC=C(C=C5)C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATG5 PPI-IN-6 Related Classifications
HY-183867 Related Classifications
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