ATG4B - autophagy related 4B cysteine peptidase Gene

Also Known as APG4B; AUTL1; HsAPG4B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23192

About ATG4B

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,637,693-241,673,857 (from NCBI)

This gene has 26 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 14.5), duodenum (RPKM 12.3) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ATG4B Products (2)

mRNA	Protein	Name
NM_013325.5	NP_037457.3	cysteine protease ATG4B isoform a
NM_178326.3	NP_847896.1	cysteine protease ATG4B isoform b

ATG4B Protein Structure

Peptidase_C54

0
100
200
300
393 a.a.

Protein Preferred Names	Protein Names
cysteine protease ATG4B	APG4 autophagy 4 homolog B

ATG4B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATG4B	Q9Y4P1	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	Protease Assay	19322194
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	X-Ray Diffraction	19322194
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	BioID	34524948
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	NMR	19322194
Intra	ATG4B	Q9Y4P1	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	20562859
Intra	ATG4B	Q9Y4P1	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	33961781
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	33961781
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	BioID	34524948
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Y2H	21900206
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	35271311
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	33961781
Cross	ATG4B	Q9Y4P1	a0a0h3lac5_mycte	Mycobacterium tuberculosis	A0A0H3LAC5	Anti Bait CoIP	30118682

Cross: Cross-species interaction Intra: Intraspecies interaction

ATG4B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82723	ATG4B Antibody (YA2468)	WB, FC	Human, Mouse, Rat
HY-P82723A	ATG4B Antibody (YA3461)	WB, FC, ELISA	Human, Mouse
HY-P84893	ATG4B Antibody (YA4590)	WB, FC, ELISA	Human, Mouse
HY-P84893A	ATG4B Antibody (YA4590)(PBS only)	WB, FC, ELISA	Human, Mouse
HY-P84894	ATG4B Antibody (YA4591)	WB, IHC-P, FC, ELISA	Human
HY-P84894A	ATG4B Antibody (YA4591)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125169	NSC 185058	Inhibitor	99.90%	Unkown
HY-112818	S130		99.43%	Unkown
HY-123967	RNF5 inhibitor inh-02		99.91%	Unkown
HY-112711	LV-320	Inhibitor	95.0%	Unkown
HY-170515	RNF5 agonist 1	Agonist	99.05%	Unkown
HY-144636	Atg4B-IN-2	Inhibitor	98.03%	Unkown
HY-W287569	STK683963		99.41%	Unkown
HY-163193	MJO445	Inhibitor	/	Unkown
HY-181936	Atg4B activator-1		/	Unkown
HY-184717	Atg4B-IN-3	Inhibitor	/	Unkown
HY-RS01149	ATG4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16929	Atg4b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23372	Atg4b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATG4B	VGNC	VGNC:60003
Canis familiaris	ATG4B	VGNC	VGNC:49762
Macaca mulatta	ATG4B	VGNC	VGNC:70104
Bos taurus	ATG4B	VGNC	VGNC:26258
Mus musculus	ATG4B	MGD	MGI:1913865
Rattus norvegicus	ATG4B	RGD	RGD:1309664
Others	ATG4B	NCBI