Atg4B-IN-2
Based on 1 Customer Validation
Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition.
For research use only. We do not sell to patients.
- Purity: 98.03%
- CAS No.: 2765008-88-4
- Formula: C21H30O3
- Molecular Weight:330.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Autophagy Compound Library
HY-L029
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Angiogenesis-Related Compound Library
HY-L088
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Lipid Metabolism Compound Library
HY-L091
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Anti-Prostate Cancer Compound Library
HY-L124
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Metabolic Enzyme Compound Library
HY-L146
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Protease Inhibitor Library
HY-L147
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Cell Death Library
HY-L162
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Anti-Drug-Resistant Compound Library
HY-L169
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Atg4B-IN-2 (compound 21f) (1-10 μM; 2 hours) restores the p62 expression in cells treated with AF (amino acid-free) in a dose-dependent manner[1].
Atg4B-IN-2 (1 and 5 μM; 2 hours) decreases moderately autophagic vesicles at 1 μM, and almost completely inhibits autophagy at 5 μM[1].
Atg4B-IN-2 (5 μM; 2 hours) inhibits Abi-induced autophagy and significantly augments apoptotic cell death and sensitivity to Abi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP cells (incubated in AF medium)[1]
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Concentration:1, 2, 5, 10 μM
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Incubation Time:2 hours (then incubated in AFM for 24 or 3 hours)
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Result:Restored the p62 expression in cells treated with AF in a dose-dependent manner.
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Cell Line:LNCaP cells (incubated in AF medium)[1]
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Concentration:1 and 5 μM
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Incubation Time:2 hours (then incubated in AFM for 24 or 3 hours)
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Result:Decreased moderately autophagic vesicles at 1 μM, and almost completely inhibited autophagy at 5 μM.
Chemical Information
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CAS No. 2765008-88-4
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Appearance Solid
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Molecular Weight 330.46
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Formula C21H30O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(C=C1)CCCCCCCCCCC)/C=C/C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (302.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0261 mL | 15.1304 mL | 30.2608 mL | 75.6521 mL |
| 5 mM | 0.6052 mL | 3.0261 mL | 6.0522 mL | 15.1304 mL | |
| 10 mM | 0.3026 mL | 1.5130 mL | 3.0261 mL | 7.5652 mL | |
| 15 mM | 0.2017 mL | 1.0087 mL | 2.0174 mL | 5.0435 mL | |
| 20 mM | 0.1513 mL | 0.7565 mL | 1.5130 mL | 3.7826 mL | |
| 25 mM | 0.1210 mL | 0.6052 mL | 1.2104 mL | 3.0261 mL | |
| 30 mM | 0.1009 mL | 0.5043 mL | 1.0087 mL | 2.5217 mL | |
| 40 mM | 0.0757 mL | 0.3783 mL | 0.7565 mL | 1.8913 mL | |
| 50 mM | 0.0605 mL | 0.3026 mL | 0.6052 mL | 1.5130 mL | |
| 60 mM | 0.0504 mL | 0.2522 mL | 0.5043 mL | 1.2609 mL | |
| 80 mM | 0.0378 mL | 0.1891 mL | 0.3783 mL | 0.9457 mL | |
| 100 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.7565 mL |
Atg4B-IN-2 Related Classifications
HY-144636 Related Classifications
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