1. Metabolic Enzyme/Protease
    Autophagy
  2. Cathepsin
    Autophagy
  3. NSC 185058

NSC 185058 

Cat. No.: HY-125169
Handling Instructions

NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. NSC185058 markedly attenuates autophagic activity.

For research use only. We do not sell to patients.

NSC 185058 Chemical Structure

NSC 185058 Chemical Structure

CAS No. : 39122-38-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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Description

NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. NSC185058 markedly attenuates autophagic activity[1].

IC50 & Target

ATG4B[1]
Autophagy[1]

In Vivo

NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].

Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (580.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6453 mL 23.2266 mL 46.4533 mL
5 mM 0.9291 mL 4.6453 mL 9.2907 mL
10 mM 0.4645 mL 2.3227 mL 4.6453 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

215.27

Formula

C₁₁H₉N₃S

CAS No.

39122-38-8

SMILES

S=C(C1=NC=CC=C1)NC2=NC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
NSC 185058
Cat. No.:
HY-125169
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NSC 185058

Cat. No.: HY-125169