RUFY4 - RUN and FYVE domain containing 4 Gene

Also Known as ZFYVE31

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 285180

About RUFY4

This gene has 11 transcripts (splice variants), 109 orthologues and 1 paralogue. Broad expression in spleen (RPKM 1.0), lymph node (RPKM 0.6) and 16 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity. Involved in autophagosome assembly; cellular response to interleukin-4; and positive regulation of macroautophagy. Located in autophagosome. [provided by Alliance of Genome Resources, Apr 2022]

RUFY4 Products (1)

mRNA Protein Name
NM_198483.4 NP_940885.2 RUN and FYVE domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
26416964 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
26416964 GOA
involved in cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
26416964 GOA
involved in positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
26416964 GOA
Cellular Component GO Annotation Evidence References Source
located in autophagosome IDA
IDA: Inferred from direct assay
26416964 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RUFY4 Protein Structure

RUN

RUN: RUN domain (41 - 163)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 571 a.a.
Protein Preferred Names Protein Names

RUN and FYVE domain-containing protein 4

RUFY4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RUFY4 Q6ZNE9 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra
RUFY4 Q6ZNE9 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra
RUFY4 Q6ZNE9 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra
RUFY4 Q6ZNE9 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
RUFY4 Q6ZNE9 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
RUFY4 Q6ZNE9 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
RUFY4 Q6ZNE9 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra
RUFY4 Q6ZNE9 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
RUFY4 Q6ZNE9 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
RUFY4 Q6ZNE9 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
RUFY4 Q6ZNE9 TRAPPC9 Homo sapiens Q96Q05
Anti Tag CoIP
33961781
Intra
RUFY4 Q6ZNE9 NDC80 Homo sapiens O14777
Validated Y2H
25416956
Intra
RUFY4 Q6ZNE9 NDC80 Homo sapiens O14777
Anti Tag CoIP
33961781
Intra
RUFY4 Q6ZNE9 NDC80 Homo sapiens O14777
Y2H Array
25416956
Intra
RUFY4 Q6ZNE9 NDC80 Homo sapiens O14777
Y2H Array
29892012
Intra
RUFY4 Q6ZNE9 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
RUFY4 Q6ZNE9 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
RUFY4 Q6ZNE9 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
RUFY4 Q6ZNE9 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
RUFY4 Q6ZNE9 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
RUFY4 Q6ZNE9 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
RUFY4 Q6ZNE9 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Melnick-Needles Syndrome

  • MNS

  • Melnick-Needles Osteodysplasty

  • Osteodysplasty Of Melnick And Needles

  • Osteochondrodysplasias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12346 RUFY4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RUFY4 RGD RGD:1560678
Mus musculus RUFY4 MGD MGI:3588214
Canis familiaris RUFY4 VGNC VGNC:57393
Macaca mulatta RUFY4 VGNC VGNC:99400
Bos taurus RUFY4 VGNC VGNC:34216
Felis catus RUFY4 VGNC VGNC:64821
Others RUFY4 NCBI