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WDFY3 - WD repeat and FYVE domain containing 3 Gene

Also Known as ALFY; BCHS; MCPH18; ZFYVE25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23001

About WDFY3

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:84,669,597-84,966,690 (from NCBI)

This gene has 12 transcripts (splice variants), 231 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 8.6), brain (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by Autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with Other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]

WDFY3 Products (1)

mRNA	Protein	Name
NM_014991.6	NP_055806.2	WD repeat and FYVE domain-containing protein 3

WDFY3 Protein Structure

PH_BEACH

Beach

WD40

FYVE

0
600
1200
1800
2400
3000
3526 a.a.

Protein Preferred Names	Protein Names
WD repeat and FYVE domain-containing protein 3	autophagy-linked FYVE protein

WDFY3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	X-Ray Diffraction	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	IF	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	Pull Down	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	Anti Tag CoIP	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	ITC	24668264
Intra	WDFY3	Q8IZQ1	ATG5	Homo sapiens	Q9H1Y0	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	ATG5	Homo sapiens	Q9H1Y0	Pull Down	20417604
Intra	WDFY3	Q8IZQ1	ATG5	Homo sapiens	Q9H1Y0	Confocal	20417604
Intra	WDFY3	Q8IZQ1	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	24668264
Intra	WDFY3	Q8IZQ1	MAP1LC3C	Homo sapiens	Q9BXW4	Anti Tag CoIP	24668264
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Pull Down	20168092
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Confocal	20168092
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20168092
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20168092
Intra	WDFY3	Q8IZQ1	MAP1LC3B	Homo sapiens	Q9GZQ8	IF	24668264
Intra	WDFY3	Q8IZQ1	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	HTT	Homo sapiens	P42858	Confocal	20417604
Intra	WDFY3	Q8IZQ1	HTT	Homo sapiens	P42858	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	GABARAPL1	Homo sapiens	Q9H0R8	ITC	24668264
Intra	WDFY3	Q8IZQ1	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	24668264
Intra	WDFY3	Q8IZQ1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	24668264
Cross	WDFY3	Q8IZQ1	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

WDFY3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84667	WDFY3 Antibody (YA4364)	IHC-P, FC, ELISA	Human
HY-P84667A	WDFY3 Antibody (YA4364)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Microcephaly 18, Primary, Autosomal Dominant	MCPH18 Primary Autosomal Dominant Microcephaly 18
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Myopathy, Centronuclear, 2	Myopathy, Centronuclear, Autosomal Recessive Autosomal Recessive Centronuclear Myopathy CNM2 Centronuclear Myopathy 2 Ar-Cnm Myotubular Myopathy, Autosomal Recessive Autosomal Recessive Myotubular Myopathy Centronuclear Myopathy Autosomal Recessive Myopathy, Centronuclear, Type 2
Microcephaly 19, Primary, Autosomal Recessive	MCPH19 Primary Autosomal Recessive Microcephaly 19 Microcephaly, Type 19, Primary, Autosomal Recessive
Microcephaly, Autosomal Dominant	Autosomal Dominant Microcephaly Microcephaly Autosomal Dominant Autosomal Dominant Primary Microcephaly Microcephaly With Autosomal Dominant Inheritance
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15756	WDFY3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WDFY3	MGD	MGI:1096875
Bos taurus	WDFY3	VGNC	VGNC:36877
Felis catus	WDFY3	VGNC	VGNC:67011
Canis familiaris	WDFY3	VGNC	VGNC:48346
Rattus norvegicus	WDFY3	RGD	RGD:1307097
Macaca mulatta	WDFY3	VGNC	VGNC:79279
Others	WDFY3	NCBI