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NCOA7 - nuclear receptor coactivator 7 Gene

Also Known as ESNA1; TLDC4; ERAP140; NCOA7-AS; Nbla00052; Nbla10993; dJ187J11.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 135112

About NCOA7

Cytogenetic location: 6q22.31-q22.32 Genomic coordinates (GRCh38): 6:125,781,115-125,932,034 (from NCBI)

This gene has 11 transcripts (splice variants), 295 orthologues and 3 paralogues. Ubiquitous expression in urinary bladder (RPKM 17.8), adrenal (RPKM 16.0) and 25 other tissues.

Summary

Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NCOA7 Products (6)

mRNA	Protein	Name
NM_001122842.3	NP_001116314.1	nuclear receptor coactivator 7 isoform 2
NM_001199619.2	NP_001186548.1	nuclear receptor coactivator 7 isoform 1
NM_001199620.2	NP_001186549.1	nuclear receptor coactivator 7 isoform 1
NM_001199621.2	NP_001186550.1	nuclear receptor coactivator 7 isoform 3
NM_001199622.2	NP_001186551.1	nuclear receptor coactivator 7 isoform 4
NM_181782.5	NP_861447.3	nuclear receptor coactivator 7 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	11971969	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	11971969	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10395741	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11971969	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCOA7 Protein Structure

LysM

TLD

0
200
400
600
800
942 a.a.

Protein Preferred Names	Protein Names
nuclear receptor coactivator 7	140 kDa estrogen receptor-associated protein

NCOA7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCOA7	Q8NI08	DIRAS1	Homo sapiens	O95057	Anti Tag CoIP	33961781
Intra	NCOA7	Q8NI08	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	NCOA7	Q8NI08	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	NCOA7	Q8NI08	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	NCOA7	Q8NI08	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	NCOA7	Q8NI08	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome	Door Syndrome Doors Syndrome Digitorenocerebral Syndrome Autosomal Recessive Deafness-Onychodystrophy Syndrome Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome DOORS Drc Syndrome Eronen Syndrome Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Brachydactyly Due To Absence Of Distal Phalanges Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome Deafness, Congenital Onychodystrophy, Recessive Form Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome
Developmental And Epileptic Encephalopathy 16	DEE16 Epileptic Encephalopathy, Early Infantile, 16 Eiee16 Developmental And Epileptic Encephalopathy, 16 Early Infantile Epileptic Encephalopathy 16 Progressive Myoclonic Epilepsy With Dystonia Pmed Progressive Myoclonus Epilepsy With Dystonia Encephalopathy, Epileptic, Early Infantile, Type 16
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Martsolf Syndrome 1	Martsolf Syndrome Cataract-Intellectual Disability-Hypogonadism Syndrome MARTS1 Marts Cataract-Mental Retardation-Hypogonadism Martsolf

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09095	NCOA7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20060	Ncoa6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCOA7	RGD	RGD:1566426
Felis catus	NCOA7	VGNC	VGNC:63743
Macaca mulatta	NCOA7	VGNC	VGNC:74998
Mus musculus	NCOA7	MGD	MGI:2444847
Canis familiaris	NCOA7	VGNC	VGNC:43664
Bos taurus	NCOA7	VGNC	VGNC:108132
Others	NCOA7	NCBI