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STK3 - serine/threonine kinase 3 Gene

Also Known as KRS1; MST2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6788

About STK3

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:98,343,975-98,942,610 (from NCBI)

This gene has 20 transcripts (splice variants), 277 orthologues and 35 paralogues. Ubiquitous expression in endometrium (RPKM 3.0), placenta (RPKM 2.4) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by Caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

STK3 Products (3)

mRNA	Protein	Name
NM_001256312.2	NP_001243241.1	serine/threonine-protein kinase 3 isoform 2
NM_001256313.2	NP_001243242.1	serine/threonine-protein kinase 3 isoform 3
NM_006281.4	NP_006272.2	serine/threonine-protein kinase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	8566796	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	8566796	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14729613	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	28087714	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	11278283	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8566796	GOA
enables transcription regulator activator activity	IGI IGI: Inferred from genetic interaction	22292086	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	15688006	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	8566796	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
acts upstream of or within positive regulation of hippo signaling	IDA IDA: Inferred from direct assay	22292086	GOA
involved in protein import into nucleus	IGI IGI: Inferred from genetic interaction	16751106	GOA
involved in protein localization to centrosome	IDA IDA: Inferred from direct assay	21076410	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8566796	GOA
acts upstream of or within protein stabilization	IMP IMP: Inferred from mutant phenotype	22292086	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in centrosome	IDA IDA: Inferred from direct assay	21076410	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19525978	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21145499	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19962960	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK3 Protein Structure

Pkinase

Mst1_SARAH

0
100
200
300
400
491 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase 3	KB-1458E12.1

STK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STK3	Q13188	FLJ13057	Homo sapiens	Q53SE7	Validated Y2H	25416956
Intra	STK3	Q13188	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	STK3	Q13188	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	STK3	Q13188	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	24366813
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	16930133
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	BioID	24255178
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	20562859
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	Y2H	21988832
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	TAP	24981860
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	24255178
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	Y2H Array	32296183
Intra	STK3	Q13188	SAV1	Homo sapiens	Q9H4B6	TAP	23455922
Intra	STK3	Q13188	TFPT	Homo sapiens	P0C1Z6-2	Validated Y2H	25416956
Intra	STK3	Q13188	TFPT	Homo sapiens	P0C1Z6-2	Y2H Array	25416956
Intra	STK3	Q13188	SLMAP	Homo sapiens	Q14BN4	Y2H Prey Pooling	25416956
Intra	STK3	Q13188	SLMAP	Homo sapiens	Q14BN4	BioID	24255178
Intra	STK3	Q13188	SLMAP	Homo sapiens	Q14BN4	Validated Y2H	25416956
Intra	STK3	Q13188	SLMAP	Homo sapiens	Q14BN4	Pull Down	32707033
Intra	STK3	Q13188	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	STK3	Q13188	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	STK3	Q13188	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	STK3	Q13188	TFPT	Homo sapiens	P0C1Z6	Y2H Array	32296183
Intra	STK3	Q13188	TFPT	Homo sapiens	P0C1Z6	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	MOB1B	Homo sapiens	Q7L9L4	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	MOB1B	Homo sapiens	Q7L9L4	Validated Y2H	32296183
Intra	STK3	Q13188	MOB1B	Homo sapiens	Q7L9L4	Y2H Array	32296183
Intra	STK3	Q13188	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	STK3	Q13188	RASSF3	Homo sapiens	Q86WH2	TAP	23455922
Intra	STK3	Q13188	RASSF3	Homo sapiens	Q86WH2	Pull Down	32707033
Intra	STK3	Q13188	RASSF3	Homo sapiens	Q86WH2	BioID	24255178
Intra	STK3	Q13188	RASSF3	Homo sapiens	Q86WH2	Anti Tag CoIP	24366813
Intra	STK3	Q13188	RASSF4	Homo sapiens	Q9H2L5	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	RASSF4	Homo sapiens	Q9H2L5	Anti Tag CoIP	24255178
Intra	STK3	Q13188	RASSF4	Homo sapiens	Q9H2L5	TAP	23455922
Intra	STK3	Q13188	RASSF4	Homo sapiens	Q9H2L5	Validated Y2H	32296183
Intra	STK3	Q13188	RASSF4	Homo sapiens	Q9H2L5	Y2H Array	32296183
Intra	STK3	Q13188	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	STK3	Q13188	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	STK3	Q13188	STK4	Homo sapiens	Q13043	BioID	24255178
Intra	STK3	Q13188	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24255178
Intra	STK3	Q13188	STK4	Homo sapiens	Q13043	TAP	23455922
Intra	STK3	Q13188	STK4	Homo sapiens	Q13043	Pull Down	32707033
Intra	STK3	Q13188	STK4	Homo sapiens	Q13043	Y2H	20920251
Intra	STK3	Q13188	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
Intra	STK3	Q13188	STK4	Homo sapiens	Q13043	Anti Tag CoIP	20562859
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0	Y2H	21988832
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0	TAP	24981860
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0	BioID	24255178
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0	Anti Tag CoIP	24255178
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0	TAP	23455922
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0	Pull Down	32707033
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0	Anti Tag CoIP	24366813
Intra	STK3	Q13188	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	STK3	Q13188	RASSF1	Homo sapiens	Q9NS23-2	Y2H	14729613
Intra	STK3	Q13188	RASSF1	Homo sapiens	Q9NS23-2	Validated Y2H	32296183
Intra	STK3	Q13188	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	STK3	Q13188	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	STK3	Q13188	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	STK3	Q13188	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	STK3	Q13188	GAD1	Homo sapiens	Q99259	Y2H Array	25416956
Intra	STK3	Q13188	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	STK3	Q13188	MOB1A	Homo sapiens	Q9H8S9	Protein Kinase Assay	23972470
Intra	STK3	Q13188	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	24255178
Intra	STK3	Q13188	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	32296183
Intra	STK3	Q13188	SNIP1	Homo sapiens	Q8TAD8	Validated Y2H	32296183
Intra	STK3	Q13188	SNIP1	Homo sapiens	Q8TAD8	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	MOB3B	Homo sapiens	Q86TA1	Validated Y2H	32296183
Intra	STK3	Q13188	MOB3B	Homo sapiens	Q86TA1	Y2H Array	32296183
Intra	STK3	Q13188	MOB3B	Homo sapiens	Q86TA1	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Y2H Prey Pooling	32296183
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Y2H Array	32296183
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Pull Down	32707033
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Y2H Prey Pooling	25416956
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	TAP	24981860
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	24255178
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	TAP	23455922
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Validated Y2H	25416956
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	BioID	24255178
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	24366813
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Y2H	20920251
Intra	STK3	Q13188	RASSF2	Homo sapiens	P50749	Y2H Array	25416956
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0-1	X-Ray Diffraction	23972470
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0-1	Pull Down	23972470
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0-1	GMS	23972470
Intra	STK3	Q13188	RASSF5	Homo sapiens	Q8WWW0-1	Protein Kinase Assay	23972470

Cross: Cross-species interaction Intra: Intraspecies interaction

STK3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80230	STK3/MST-2 Antibody (YA282)	WB, IHC-P, IP	Human, Mouse
HY-P82338	STK3/MST-2Antibody (YA2083)	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
HY-P82338A	STK3/MST-2Antibody (YA2083)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat, Hamster

Related Diseases

Diseases	Alias
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132969	SBP-3264		98.50%	Unkown
HY-137340	WH-10417-099	Degrader	98.14%	Unkown
HY-178974	STK10-IN-1	Inhibitor	/	Unkown
HY-RS13927	STK24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13930	STK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19934	Pkn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19960	Stk3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26462	Stk3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STK3	VGNC	VGNC:81676
Mus musculus	STK3	MGD	MGI:1928487
Macaca mulatta	STK3	VGNC	VGNC:81586
Bos taurus	STK3	VGNC	VGNC:35393
Rattus norvegicus	STK3	RGD	RGD:68412
Canis familiaris	STK3	VGNC	VGNC:46911
Others	STK3	NCBI