SLMAP - sarcolemma associated protein Gene

Also Known as SLAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7871

About SLMAP

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:57,756,309-57,930,013 (from NCBI)

This gene has 40 transcripts (splice variants), 209 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 29.5), esophagus (RPKM 29.0) and 24 other tissues.

Summary

This gene encodes a component of a conserved striatin-interacting Phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and Apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

SLMAP Products (28)

mRNA	Protein	Name
NM_001304420.3	NP_001291349.1	sarcolemmal membrane-associated protein isoform a
NM_001304421.2	NP_001291350.1	sarcolemmal membrane-associated protein isoform c
NM_001304422.3	NP_001291351.1	sarcolemmal membrane-associated protein isoform d
NM_001304423.3	NP_001291352.1	sarcolemmal membrane-associated protein isoform e
NM_001311178.2	NP_001298107.1	sarcolemmal membrane-associated protein isoform f
NM_001311179.2	NP_001298108.1	sarcolemmal membrane-associated protein isoform g
NM_001377538.1	NP_001364467.1	sarcolemmal membrane-associated protein isoform h
NM_001377539.1	NP_001364468.1	sarcolemmal membrane-associated protein isoform i
NM_001377540.1	NP_001364469.1	sarcolemmal membrane-associated protein isoform j
NM_001377541.1	NP_001364470.1	sarcolemmal membrane-associated protein isoform k
NM_001377542.1	NP_001364471.1	sarcolemmal membrane-associated protein isoform q
NM_001377545.1	NP_001364474.1	sarcolemmal membrane-associated protein isoform l
NM_001377549.1	NP_001364478.1	sarcolemmal membrane-associated protein isoform n
NM_001377551.1	NP_001364480.1	sarcolemmal membrane-associated protein isoform aa
NM_001377552.1	NP_001364481.1	sarcolemmal membrane-associated protein isoform o
NM_001377555.1	NP_001364484.1	sarcolemmal membrane-associated protein isoform p
NM_001377557.1	NP_001364486.1	sarcolemmal membrane-associated protein isoform c
NM_001377559.1	NP_001364488.1	sarcolemmal membrane-associated protein isoform r
NM_001377562.1	NP_001364491.1	sarcolemmal membrane-associated protein isoform bb
NM_001377921.1	NP_001364850.1	sarcolemmal membrane-associated protein isoform s
NM_001377922.1	NP_001364851.1	sarcolemmal membrane-associated protein isoform t
NM_001377923.1	NP_001364852.1	sarcolemmal membrane-associated protein isoform u
NM_001377924.1	NP_001364853.1	sarcolemmal membrane-associated protein isoform v
NM_001377925.1	NP_001364854.1	sarcolemmal membrane-associated protein isoform w
NM_001377926.1	NP_001364855.1	sarcolemmal membrane-associated protein isoform x
NM_001377927.1	NP_001364856.1	sarcolemmal membrane-associated protein isoform y
NM_001377928.1	NP_001364857.1	sarcolemmal membrane-associated protein isoform z
NM_007159.5	NP_009090.2	sarcolemmal membrane-associated protein isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23386615	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	29063833	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	29063833	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23064965	GOA
involved in regulation of membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	23064965	GOA
involved in regulation of sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	23064965	GOA
involved in regulation of voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	23064965	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	29063833	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	29063833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLMAP Protein Structure

FHA

0
200
400
600
828 a.a.

Protein Preferred Names	Protein Names
sarcolemmal membrane-associated protein

SLMAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLMAP	Q14BN4	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24255178
Intra	SLMAP	Q14BN4	STK4	Homo sapiens	Q13043	BioID	24255178
Intra	SLMAP	Q14BN4	STK4	Homo sapiens	Q13043	Confocal	24255178
Intra	SLMAP	Q14BN4	STK4	Homo sapiens	Q13043	Y2H	23386615
Intra	SLMAP	Q14BN4	STK3	Homo sapiens	Q13188	Y2H Array	25416956
Intra	SLMAP	Q14BN4	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24255178

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Cerebral Cavernous Malformations 3	Cerebral Cavernous Malformation 3 CCM3 Cerebral Cavernous Malformations-3 Cavernous Angiomatous Malformations Cavernous Hemangioma Of The Brain Cerebral Capillary Malformations Cerebral Cavernoma Familial Cavernous Angioma Cerebral Cavernous Malformations, Type 3
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13380	SLMAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22808	Slmap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29323	Slmap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLMAP	MGD	MGI:1933549
Canis familiaris	SLMAP	VGNC	VGNC:46513
Macaca mulatta	SLMAP	VGNC	VGNC:77723
Felis catus	SLMAP	VGNC	VGNC:65455
Rattus norvegicus	SLMAP	RGD	RGD:1307674
Bos taurus	SLMAP	VGNC	VGNC:34969
Others	SLMAP	NCBI