NCOR2 - nuclear receptor corepressor 2 Gene

Also Known as SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9612

About NCOR2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:124,324,415-124,567,612 (from NCBI)

This gene has 24 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 94 phenotypes. Ubiquitous expression in fat (RPKM 14.9), lung (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

NCOR2 Products (3)

mRNA	Protein	Name
NM_001077261.4	NP_001070729.2	nuclear receptor corepressor 2 isoform 2
NM_001206654.2	NP_001193583.1	nuclear receptor corepressor 2 isoform 3
NM_006312.6	NP_006303.4	nuclear receptor corepressor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	10713164	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	11804585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9605924	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	18052923	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	12628926	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20812024	GOA
involved in negative regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20812024	GOA
involved in negative regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	20388878	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10097068	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12628926	GOA
involved in regulation of cellular ketone metabolic process	IMP IMP: Inferred from mutant phenotype	19955185	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20388878	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	16030140	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	21328542	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10097068	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	11804585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCOR2 Protein Structure

Myb_DNA-binding

0
400
800
1200
1600
2000
2400
2514 a.a.

Protein Preferred Names	Protein Names
nuclear receptor corepressor 2	CTG repeat protein 26

NCOR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCOR2	Q9Y618	TBL1X	Homo sapiens	O60907-2	Pull Down	21240272
Intra	NCOR2	Q9Y618	HDAC1	Homo sapiens	Q13547	Affinity Chrom	11013263
Intra	NCOR2	Q9Y618	TP53	Homo sapiens	P04637	Competition Binding	24449765
Intra	NCOR2	Q9Y618	TP53	Homo sapiens	P04637	Pull Down	24449765
Intra	NCOR2	Q9Y618	THRB	Homo sapiens	P10828-1	EMSA	9605924
Intra	NCOR2	Q9Y618	THRB	Homo sapiens	P10828-1	Pull Down	9605924
Intra	NCOR2	Q9Y618	E2F1	Homo sapiens	Q01094	TAP	20195357
Intra	NCOR2	Q9Y618	E2F1	Homo sapiens	Q01094	Display Tech	20195357
Intra	NCOR2	Q9Y618	HDAC3	Homo sapiens	O15379	Competition Binding	24449765
Intra	NCOR2	Q9Y618	HDAC3	Homo sapiens	O15379	Affinity Chrom	11013263
Intra	NCOR2	Q9Y618	RBPJ	Homo sapiens	Q06330	Y2H	21475249
Intra	NCOR2	Q9Y618	RBPJ	Homo sapiens	Q06330	Y2H	10713164
Intra	NCOR2	Q9Y618	SNW1	Homo sapiens	Q13573	Y2H	14985122
Intra	NCOR2	Q9Y618	SNW1	Homo sapiens	Q13573	Y2H	10713164
Intra	NCOR2	Q9Y618	GPS2	Homo sapiens	Q13227	Pull Down	21240272
Intra	NCOR2	Q9Y618	AHR	Homo sapiens	P35869	CoIP	10395741
Intra	NCOR2	Q9Y618	ARNT	Homo sapiens	P27540	CoIP	10395741

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Thrombophilia, X-Linked, Due To Factor Ix Defect	THPH8 Deep Venous Thrombosis, Protection Against X-Linked Thrombophilia Due To Factor Ix Defect Thrombophilia, X-Linked, Due To Factor 9 Defect Thrombophilia 8, X-Linked, Due To Factor Ix Defect
Retinitis Pigmentosa 90	RP90 Retinitis Pigmentosa, Type 90
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173033	MI-883		99.57%	Unkown
HY-P3364A	Ac-QPKK(Ac)-AMC acetate	Substrate	99.38%	Unkown
HY-RS09097	NCOR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19464	Ncor2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25957	Ncor2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NCOR2	VGNC	VGNC:52954
Mus musculus	NCOR2	MGD	MGI:1337080
Macaca mulatta	NCOR2	VGNC	VGNC:75148
Bos taurus	NCOR2	VGNC	VGNC:58394
Rattus norvegicus	NCOR2	RGD	RGD:1310293
Felis catus	NCOR2	VGNC	VGNC:80458
Others	NCOR2	NCBI