ARNT - aryl hydrocarbon receptor nuclear translocator Gene

Also Known as HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 405

About ARNT

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,809,713-150,876,599 (from NCBI)

This gene has 12 transcripts (splice variants), 212 orthologues, 6 paralogues and is associated with 69 phenotypes. Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound Aryl Hydrocarbon Receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

ARNT Products (8)

mRNA	Protein	Name
NM_001197325.2	NP_001184254.1	aryl hydrocarbon receptor nuclear translocator isoform 4
NM_001286035.2	NP_001272964.1	aryl hydrocarbon receptor nuclear translocator isoform 5
NM_001286036.2	NP_001272965.1	aryl hydrocarbon receptor nuclear translocator isoform 6
NM_001350224.2	NP_001337153.1	aryl hydrocarbon receptor nuclear translocator isoform 7
NM_001350225.2	NP_001337154.1	aryl hydrocarbon receptor nuclear translocator isoform 8
NM_001350226.2	NP_001337155.1	aryl hydrocarbon receptor nuclear translocator isoform 9
NM_001668.4	NP_001659.1	aryl hydrocarbon receptor nuclear translocator isoform 1
NM_178427.3	NP_848514.1	aryl hydrocarbon receptor nuclear translocator isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	29454749	GOA
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7539918	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	7539918	GOA
enables aryl hydrocarbon receptor binding	IPI IPI: Inferred from physical interaction	9079689	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23275542	GOA
contributes to nuclear receptor activity	IDA IDA: Inferred from direct assay	34521881	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10395741	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	16181639	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9079689	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16181639	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7539918	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28396409	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	29454749	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7539918	GOA
involved in positive regulation of vascular endothelial growth factor production	IDA IDA: Inferred from direct assay	8756616	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	8756616	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	7539918	GOA
part of nuclear aryl hydrocarbon receptor complex	IDA IDA: Inferred from direct assay	34521881	GOA
located in nucleus	IDA IDA: Inferred from direct assay	34521881	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARNT Protein Structure

HLH

PAS

PAS_11

0
200
400
600
789 a.a.

Protein Preferred Names	Protein Names
aryl hydrocarbon receptor nuclear translocator	class E basic helix-loop-helix protein 2

ARNT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARNT	P27540	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	20932347
Intra	ARNT	P27540	HIF1A	Homo sapiens	Q16665	NMR	14668441
Intra	ARNT	P27540	HIF1A	Homo sapiens	Q16665	Y2H	9704006
Intra	ARNT	P27540	EPAS1	Homo sapiens	Q99814	Y2H	11018023
Intra	ARNT	P27540	EPAS1	Homo sapiens	Q99814	NMR	14668441
Intra	ARNT	P27540	AHR	Homo sapiens	P35869	Anti Tag CoIP	33961781
Intra	ARNT	P27540	AHR	Homo sapiens	P35869	Anti Tag CoIP	28514442
Intra	ARNT	P27540	AHR	Homo sapiens	P35869	CoIP	10395741
Intra	ARNT	P27540	NCOA7	Homo sapiens	Q8NI08	CoIP	10395741
Intra	ARNT	P27540	NCOR2	Homo sapiens	Q9Y618	CoIP	10395741

Cross: Cross-species interaction Intra: Intraspecies interaction

ARNT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80705	HIF1 beta Antibody (YA385)	WB, IHC-P	Human, Mouse, Rat, Hamster
HY-P80705A	HIF1 beta Antibody (YA385)(PBS only)	WB, IHC-P	Human, Mouse, Rat, Hamster
HY-P85750	HIF1 beta Antibody (YA5442)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Esophagus Carcinoma In Situ	Carcinoma In Situ Of Esophagus Carcinoma In Situ Of Oesophagus Oesophagus Carcinoma In Situ Severe Esophageal Dysplasia Stage 0 Carcinoma Of The Esophagus Stage 0 Carcinoma Of The Oesophagus Severe Oesophageal Dysplasia
Primary Polycythemia	Familial Erythrocytosis Familiar Polycythemia Benign Familial Polycythemia Congenital Erythrocytosis Familial Polycythemia Hereditary Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Familial Polycythemia Vera Primary Familial Polycythaemia Primary Inherited Polycythaemia
Erythrocytosis, Familial, 2	Chuvash Polycythemia ECYT2 Familial Erythrocytosis 2 Autosomal Recessive Benign Erythrocytosis Polycythemia, Vhl-Dependent Chuvash Erythromatosis Chuvash Type Polycythemia Chuvash Erythrocytosis Von Hippel-Lindau-Dependent Polycythemia Polycythemia Chuvash Type Vhl-Dependent Polycythemia Erythrocytosis, Familial, Type 2
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16031A	AFP464		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120087	KG-548	Inhibitor	99.90%	Unkown
HY-D0932	Sudan IV		98.0%	Unkown
HY-19621	THS-044	Modulator	99.67%	Unkown
HY-159644	Casdatifan		96.37%	Unkown
HY-112374	NPAS3-IN-1	Inhibitor	98.72%	Unkown
HY-RS01011	ARNT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W012248	KG-655	Inhibitor	99.87%	Unkown
HY-183117	NEO-811	Degrader	/	Unkown
HY-183583	HIF-2α-IN-18	Inhibitor	/	Unkown
HY-186020	L-4-Aminoarabinose-bactoprenyl phosphate		/	Unkown
HY-RS01012	ARNT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08421	MIA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-D0932S	Sudan IV-d6		/	Unkown
HY-RS18908	Arnt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25399	Arnt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown