L-4-Aminoarabinose-bactoprenyl phosphate

L-4-Aminoarabinose-bactoprenyl phosphate (L-4-Aminoarabinose-BP) is a substrate of the ArnT enzyme and participates in lipid A modification through covalent bonding. L-4-Aminoarabinose-bactoprenyl phosphate transfers L-4-aminoarabinose (Ara4N) to the lipid A portion of lipopolysaccharide (LPS), mediating cationic modification of lipid A, thereby conferring resistance to cationic antimicrobial peptides (CAMPs) in Gram-negative bacteria. L-4-Aminoarabinose-bactoprenyl phosphate is an endogenous intermediate synthesized in vivo by a series of enzymes such as ArnC and ArnD encoded by the arn operon in Gram-negative bacteria such as Escherichia coli.

• Data Sheet (261 KB)