1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

THS-044 

Cat. No.: HY-19621 Purity: 98.48%
Handling Instructions

THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.

For research use only. We do not sell to patients.

THS-044 Chemical Structure

THS-044 Chemical Structure

CAS No. : 62054-67-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2160 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

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  • References

Description

THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. Target: HIF2α Limited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4337 mL 17.1686 mL 34.3371 mL
5 mM 0.6867 mL 3.4337 mL 6.8674 mL
10 mM 0.3434 mL 1.7169 mL 3.4337 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

291.23

Formula

C₁₁H₁₂F₃N₃O₃

CAS No.

62054-67-5

SMILES

FC(C1=CC=C(NN2CCOCC2)C([N+]([O-])=O)=C1)(F)F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
THS-044
Cat. No.:
HY-19621
Quantity:

THS-044

Cat. No.: HY-19621