62054-67-5
62054-67-5
Chemical Structure
THS-044
- CAS No.: 62054-67-5
- Formula:C11H12F3N3O3
- Molecular Weight:291.23
IUPAC Name: N-(2-nitro-4-(trifluoromethyl)phenyl)morpholin-4-amine
InChIKey: XUPDNGHJBHPAKD-UHFFFAOYSA-N
SMILES: FC(C1=CC=C(NN2CCOCC2)C([N+]([O-])=O)=C1)(F)F
Biological Activity: THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 can be used for the study of diseases related to hypoxia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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THS-044 | 99.37% | THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 can be used for the study of diseases related to hypoxia. | ||||||||||||||||||||
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References
Keywords
