2. GPCR/G Protein
  3. GPR109A
  4. GPCR agonist-2

GPCR agonist-2 (Compound 5j) is a GPCR GPR109b (HM74) agonist, with a pEC50 value of 6.51. GPCR agonist-2 can be used for research of lipid disorders.

For research use only. We do not sell to patients.

GPCR agonist-2 Chemical Structure

GPCR agonist-2 Chemical Structure

CAS No. : 291528-35-3

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10 mg USD 50 In-stock
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Based on 1 publication(s) in Google Scholar

GPCR agonist-2 Related Antibodies

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Description

GPCR agonist-2 (Compound 5j) is a GPCR GPR109b (HM74) agonist, with a pEC50 value of 6.51. GPCR agonist-2 can be used for research of lipid disorders[1].

Molecular Weight

222.20

Formula

C10H10N2O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC=C(NC2CC2)C([N+]([O-])=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (562.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5005 mL 22.5023 mL 45.0045 mL
5 mM 0.9001 mL 4.5005 mL 9.0009 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.93%

COA (249 KB) HNMR (246 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5005 mL 22.5023 mL 45.0045 mL 112.5113 mL
5 mM 0.9001 mL 4.5005 mL 9.0009 mL 22.5023 mL
10 mM 0.4500 mL 2.2502 mL 4.5005 mL 11.2511 mL
15 mM 0.3000 mL 1.5002 mL 3.0003 mL 7.5008 mL
20 mM 0.2250 mL 1.1251 mL 2.2502 mL 5.6256 mL
25 mM 0.1800 mL 0.9001 mL 1.8002 mL 4.5005 mL
30 mM 0.1500 mL 0.7501 mL 1.5002 mL 3.7504 mL
40 mM 0.1125 mL 0.5626 mL 1.1251 mL 2.8128 mL
50 mM 0.0900 mL 0.4500 mL 0.9001 mL 2.2502 mL
60 mM 0.0750 mL 0.3750 mL 0.7501 mL 1.8752 mL
80 mM 0.0563 mL 0.2813 mL 0.5626 mL 1.4064 mL
100 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1251 mL
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GPCR agonist-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPCR agonist-2291528-35-3GPCR agonist2GPCR agonist 2GPR109AHM74APUMA-GHCA2HCAR2 GPCRGPR109bHM74lipid disorderlipolysisInhibitorinhibitorinhibit

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