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Cat. No.: HY-W777526

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Nitisinone-¹³C₆

Name: Nitisinone-13C6
Brand: MedChemExpress
SKU: HY-W777526
Price: 871.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Nitisinone-¹³C₆ is a ¹³C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism.

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CAS No.: 1246815-63-3
Formule: C₈¹³C₆H₁₀F₃NO₅
Masse moléculaire:335.18

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Nitisinone-¹³C₆ Chemical Structure

CAS No.: 1246815-63-3

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1246815-63-3
Unlabeled Cas 104206-65-7
Masse moléculaire 335.18
Formule C₈¹³C₆H₁₀F₃NO₅
SMILES

O=C([13CH]1[13C]([13CH2][13CH2][13CH2][13C]1=O)=O)C2=C(C=C(C=C2)C(F)(F)F)[N+]([O-])=O
Livraison

Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Nitisinone-¹³C₆

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Pregnanetriol

S-Acetylglutathione

L-Phenylalanine-13C6

Bodipy C12-ceramide

α-Androstenol

Melengestrol acetate

Carbetocin acetate

Cloprostenol isopropyl ester

5β-Dihydroprogesterone

17-Epiestriol

Melengestrol acetate (Standard)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

Nitisinone-13C6

Psychosine

Pregnanetriol

S-Acetylglutathione

L-Phenylalanine-13C6

Bodipy C12-ceramide

α-Androstenol

Melengestrol acetate

Carbetocin acetate

Cloprostenol isopropyl ester

5β-Dihydroprogesterone

17-Epiestriol

Melengestrol acetate (Standard)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Nitisinone-13C6 Related Classifications

HY-W777526 Related Classifications

Bioz

Nitisinone-¹³C₆

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