Sudan IV-d6
Sudan IV-d6 (Solvent Red 24-d6) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
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- No. CAS: 1014689-18-9
- Fòrmula: C24H14D6N4O
- Peso molecular:386.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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CYP1A1 |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1014689-18-9
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Unlabeled Cas 85-83-6
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Peso molecular 386.48
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Fòrmula C24H14D6N4O
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SMILES
OC1=C([2H])C([2H])=C2C([2H])=C([2H])C([2H])=C([2H])C2=C1/N=N/C3=CC=C(C=C3C)/N=N/C4=CC=CC=C4C
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Synonyms
Solvent Red 24-d6; C.I. 26105-d6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Refat NA, et al. The induction of cytochrome P450 1A1 by sudan dyes. J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):77-84. [Content Brief]
[2]. Lu D, et al. Binding of Sudan II and Sudan IV to bovine serum albumin: comparison studies. Food Chem Toxicol. 2011 Dec;49(12):3158-64. [Content Brief]
[3]. Huang ST, et al. An ultrasensitive and selective fluorescence assay for Sudan I and III against the influence of Sudan II and IV. Biosens Bioelectron. 2013 Apr 15;42:136-40. [Content Brief]
[4]. Pérez-Sanz F, Riquelme-Pérez M, Martínez-Barba E, de la Peña-Moral J, Salazar Nicolás A, Carpes-Ruiz M, Esteban-Gil A, Legaz-García MDC, Parreño-González MA, Ramírez P, Martínez CM. Efficiency of Machine Learning Algorithms for the Determination of Macrovesicular Steatosis in Frozen Sections Stained with Sudan to Evaluate the Quality of the Graft in Liver Transplantation. Sensors (Basel). 2021 Mar 12;21(6):1993. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sudan IV-d6 Related Classifications
HY-D0932S Related Classifications
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