Sudan IV-d6
Sudan IV-d6 (Solvent Red 24-d6) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1014689-18-9
- 分子式: C24H14D6N4O
- 分子量:386.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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CYP1A1 |
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 1014689-18-9
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非標識Cas 85-83-6
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分子量 386.48
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分子式 C24H14D6N4O
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SMILES
OC1=C([2H])C([2H])=C2C([2H])=C([2H])C([2H])=C([2H])C2=C1/N=N/C3=CC=C(C=C3C)/N=N/C4=CC=CC=C4C
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別名
Solvent Red 24-d6; C.I. 26105-d6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Refat NA, et al. The induction of cytochrome P450 1A1 by sudan dyes. J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):77-84. [Content Brief]
[2]. Lu D, et al. Binding of Sudan II and Sudan IV to bovine serum albumin: comparison studies. Food Chem Toxicol. 2011 Dec;49(12):3158-64. [Content Brief]
[3]. Huang ST, et al. An ultrasensitive and selective fluorescence assay for Sudan I and III against the influence of Sudan II and IV. Biosens Bioelectron. 2013 Apr 15;42:136-40. [Content Brief]
[4]. Pérez-Sanz F, Riquelme-Pérez M, Martínez-Barba E, de la Peña-Moral J, Salazar Nicolás A, Carpes-Ruiz M, Esteban-Gil A, Legaz-García MDC, Parreño-González MA, Ramírez P, Martínez CM. Efficiency of Machine Learning Algorithms for the Determination of Macrovesicular Steatosis in Frozen Sections Stained with Sudan to Evaluate the Quality of the Graft in Liver Transplantation. Sensors (Basel). 2021 Mar 12;21(6):1993. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sudan IV-d6 関連分類
HY-D0932S 関連分類
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