NLK - nemo like kinase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51701

About NLK

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,042,677-28,206,074 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 18.0), adrenal (RPKM 18.0) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in protein stabilization and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NLK Products (1)

mRNA Protein Name
NM_016231.5 NP_057315.3 serine/threonine-protein kinase NLK

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16714285 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
26588989 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16714285 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to osmotic stress IDA
IDA: Inferred from direct assay
26588989 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
26588989 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
25512613 GOA
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15004007 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLK Protein Structure

Pkinase

Pkinase: Protein kinase domain (141 - 427)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 527 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase NLK

NLK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NLK Q9UBE8 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
Intra
NLK Q9UBE8 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
32296183
Intra
NLK Q9UBE8 QRICH1 Homo sapiens Q2TAL8
Y2H Prey Pooling
25416956
Intra
NLK Q9UBE8 QRICH1 Homo sapiens Q2TAL8
Y2H Array
25416956
Intra
NLK Q9UBE8 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
21988832
Intra
NLK Q9UBE8 SMAD4 Homo sapiens Q13485
Confocal
21988832
Intra
NLK Q9UBE8 SMAD4 Homo sapiens Q13485
Y2H Array
21988832
Intra
NLK Q9UBE8 SMAD4 Homo sapiens Q13485
TAP
23602568
Intra
NLK Q9UBE8 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
NLK Q9UBE8 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
NLK Q9UBE8 GRN Homo sapiens P28799
Y2H Array
31515488
Intra
NLK Q9UBE8 GRN Homo sapiens P28799
Y2H Array
25416956
Intra
NLK Q9UBE8 GRN Homo sapiens P28799
Y2H Prey Pooling
25416956
Intra
NLK Q9UBE8 TFDP1 Homo sapiens Q14186
Anti Bait CoIP
22773187
Intra
NLK Q9UBE8 DAPK3 Homo sapiens O43293
Anti Bait CoIP
21454679
Intra
NLK Q9UBE8 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
NLK Q9UBE8 RCHY1 Homo sapiens Q96PM5
Confocal
21988832
Intra
NLK Q9UBE8 RCHY1 Homo sapiens Q96PM5
Y2H Array
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NLK Proteins

Cat. No. Product Name Accession Purity
HY-P76517 NLK/Nemo Like Kinase Protein, Human (Active, sf9, His-GST) Q9UBE8 (V121-E527) ≥ 90%, as determined by reducing SDS-PAGE.

NLK Antibodies

Cat. No. Product Name Application Reactivity
HY-P83194 NLK Antibody (YA2939) WB, FC Human

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Leber Congenital Amaurosis 1

  • LCA1

  • Amaurosis Congenita Of Leber I

  • Lca

  • Retinal Blindness, Congenital

  • Crb

  • Leber Congenital Amaurosis Type I

  • Leber Congenital Amaurosis, Type 1

  • Amaurosis Congenita Of Leber, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-RS05639 GPI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09344 NLK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17483 Nlk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23184 Gpi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23941 Nlk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NLK RGD RGD:1561602
Mus musculus NLK MGD MGI:1201387
Bos taurus NLK VGNC VGNC:32111
Macaca mulatta NLK VGNC VGNC:75277
Felis catus NLK VGNC VGNC:63824
Canis familiaris NLK VGNC VGNC:43841
Others NLK NCBI