RCHY1 - ring finger and CHY zinc finger domain containing 1 Gene

Homo sapiens

Also known as ZCHY; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996

Gene ID: 25898 | Gene type: protein coding

About RCHY1

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,479,033-75,514,715 (from NCBI)

This gene has 13 transcripts (splice variants) and 155 orthologues. Ubiquitous expression in thyroid (RPKM 7.9), bone marrow (RPKM 6.3) and 25 other tissues.

Summary

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

RCHY1 Products(8)

mRNA	Protein	Name
NM_001009922.3	NP_001009922.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 3
NM_001278536.2	NP_001265465.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 4
NM_001278537.2	NP_001265466.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 5
NM_001278538.2	NP_001265467.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 6
NM_001278539.2	NP_001265468.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_001387136.1	NP_001374065.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_001387137.1	NP_001374066.1	RING finger and CHY zinc finger domain-containing protein 1 isoform 7
NM_015436.4	NP_056251.2	RING finger and CHY zinc finger domain-containing protein 1 isoform 1

RCHY1 Protein Structure

zf-CHY

zf-RING_2

zinc_ribbon_6

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

RING finger and CHY zinc finger domain-containing protein 1

CH-rich interacting match with PLAG1

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11786	RCHY1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RCHY1	VGNC	VGNC:64549
Bos taurus	RCHY1	VGNC	VGNC:33829
Rattus norvegicus	RCHY1	RGD	RGD:1359180
Canis familiaris	RCHY1	VGNC	VGNC:45443
Macaca mulatta	RCHY1	VGNC	VGNC:76753
Mus musculus	RCHY1	MGD	MGI:1915348

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