SEMA4C - semaphorin 4C Gene
Also Known as SEMAF; SEMAI; SEMACL1; M-SEMA-F
Species: Homo sapiens
About SEMA4C
This gene has 6 transcripts (splice variants), 201 orthologues and 19 paralogues. Ubiquitous expression in placenta (RPKM 20.2), endometrium (RPKM 13.1) and 24 other tissues.
Summary
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
SEMA4C Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_017789.5 | NP_060259.4 | semaphorin-4C precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in muscle cell differentiation |
IDA
IDA: Inferred from direct assay
|
17498836 | GOA |
| involved in positive regulation of stress-activated MAPK cascade |
IDA
IDA: Inferred from direct assay
|
17498836 | GOA |
SEMA4C Protein Structure
Sema: Sema domain (55 - 480)
PSI: Plexin repeat (499 - 530)
- 0
- 200
- 400
- 600
- 833 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
semaphorin-4C |
|
SEMA4C Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SEMA4C | Q9C0C4 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | CACNA1C | Homo sapiens | Q13936 | 37207277 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | HCN1 | Homo sapiens | O60741 | 37207277 | |
|
Intra
|
SEMA4C | Q9C0C4 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | PNMA1 | Homo sapiens | Q8ND90 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | PNMA1 | Homo sapiens | Q8ND90 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | PNMA1 | Homo sapiens | Q8ND90 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
SEMA4C | Q9C0C4 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
SEMA4C | Q9C0C4 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
SEMA4C | Q9C0C4 | USHBP1 | Homo sapiens | Q8N6Y0 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | RCHY1 | Homo sapiens | Q96PM5 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Intra
|
SEMA4C | Q9C0C4 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
SEMA4C | Q9C0C4 | PEX1 | Homo sapiens | O43933 | 32814053 | |
|
Intra
|
SEMA4C | Q9C0C4 | PEX1 | Homo sapiens | O43933 | 32814053 | |
|
Intra
|
SEMA4C | Q9C0C4 | PEX1 | Homo sapiens | O43933 | 32814053 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cri-Du-Chat Syndrome |
|
|
| Kallmann Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | SEMA4C | VGNC | VGNC:103862 |
| Canis familiaris | SEMA4C | VGNC | VGNC:45996 |
| Rattus norvegicus | SEMA4C | RGD | RGD:1562837 |
| Mus musculus | SEMA4C | MGD | MGI:109252 |
| Bos taurus | SEMA4C | VGNC | VGNC:34435 |
| Felis catus | SEMA4C | VGNC | VGNC:64994 |
| Others | SEMA4C | NCBI |