WDR74 - WD repeat domain 74 Gene

Also Known as Nsa1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54663

About WDR74

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,832,905-62,841,809 (from NCBI)

This gene has 17 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in bone marrow (RPKM 9.1), ovary (RPKM 4.9) and 25 other tissues.

Summary

Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

WDR74 Products (8)

mRNA Protein Name
NM_001307977.1 NP_001294906.1 WD repeat-containing protein 74 isoform 2
NM_001369447.1 NP_001356376.1 WD repeat-containing protein 74 isoform 3
NM_001369448.1 NP_001356377.1 WD repeat-containing protein 74 isoform 4
NM_001369449.1 NP_001356378.1 WD repeat-containing protein 74 isoform 4
NM_001369450.1 NP_001356379.1 WD repeat-containing protein 74 isoform 1
NM_001369451.1 NP_001356380.1 WD repeat-containing protein 74 isoform 1
NM_001369453.1 NP_001356382.1 WD repeat-containing protein 74 isoform 1
NM_018093.3 NP_060563.2 WD repeat-containing protein 74 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
29107693 GOA
involved in ribosomal large subunit biogenesis IMP
IMP: Inferred from mutant phenotype
26456651 GOA
Cellular Component GO Annotation Evidence References Source
part of nuclear exosome (RNase complex) IDA
IDA: Inferred from direct assay
26456651 GOA
colocalizes with nucleolus IDA
IDA: Inferred from direct assay
26456651 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
12429849 GOA
located in nucleolus IMP
IMP: Inferred from mutant phenotype
29107693 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28416111 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR74 Protein Structure

WD40

WD40: WD domain, G-beta repeat (269 - 295)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 74

  • NOP seven-associated protein 1

WDR74 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WDR74 Q6RFH5 RCHY1 Homo sapiens Q96PM5
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lateral Ventricle Meningioma

  • Meningioma Of The Lateral Ventricle
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15795 WDR74 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WDR74 VGNC VGNC:48386
Felis catus WDR74 VGNC VGNC:67053
Bos taurus WDR74 VGNC VGNC:36918
Rattus norvegicus WDR74 RGD RGD:1582881
Macaca mulatta WDR74 VGNC VGNC:79509
Mus musculus WDR74 MGD MGI:2147427
Others WDR74 NCBI