NKD2 - NKD inhibitor of WNT signaling pathway 2 Gene

Also Known as Naked2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 85409

About NKD2

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,008,802-1,038,943 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 194 orthologues and 1 paralogue. Broad expression in lung (RPKM 6.0), skin (RPKM 2.9) and 15 other tissues.

Summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

NKD2 Products (2)

mRNA Protein Name
NM_001271082.2 NP_001258011.1 protein naked cuticle homolog 2 isoform 2
NM_033120.4 NP_149111.1 protein naked cuticle homolog 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ATPase binding IPI
IPI: Inferred from physical interaction
18504258 GOA
enables growth factor binding IPI
IPI: Inferred from physical interaction
15064403 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
17045239 GOA
enables myosin heavy chain binding IPI
IPI: Inferred from physical interaction
18504258 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15064403 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
18757723 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in Golgi vesicle fusion to target membrane IMP
IMP: Inferred from mutant phenotype
17553928 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
20177058 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15687260 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20177058 GOA
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
15064403 GOA
involved in positive regulation of protein processing IDA
IDA: Inferred from direct assay
15064403 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
17553928 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
17553928 GOA
located in cell periphery IDA
IDA: Inferred from direct assay
15064403 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
15064403 GOA
located in exocytic vesicle IDA
IDA: Inferred from direct assay
18504258 GOA
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
20177058 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18504258 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein naked cuticle homolog 2

  • Dvl-binding protein NKD2

NKD2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
NKD2 Q969F2 TGFA Homo sapiens P01135
Y2H
15064403
Intra
NKD2 Q969F2 RNF25 Homo sapiens Q96BH1
Anti Bait CoIP
18757723
Intra
NKD2 Q969F2 RNF25 Homo sapiens Q96BH1
Anti Tag CoIP
18757723
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09318 NKD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus NKD2 VGNC VGNC:63814
Rattus norvegicus NKD2 RGD RGD:1311459
Macaca mulatta NKD2 VGNC VGNC:75199
Mus musculus NKD2 MGD MGI:1919543
Bos taurus NKD2 VGNC VGNC:59353
Canis familiaris NKD2 VGNC VGNC:54105
Others NKD2 NCBI