NKD2 - NKD inhibitor of WNT signaling pathway 2 Gene

Homo sapiens

Also known as Naked2

Gene ID: 85409 | Gene type: protein coding

About NKD2

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,008,802-1,038,943 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 194 orthologues and 1 paralogue. Broad expression in lung (RPKM 6.0), skin (RPKM 2.9) and 15 other tissues.

Summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

NKD2 Products(2)

mRNA	Protein	Name
NM_001271082.2	NP_001258011.1	protein naked cuticle homolog 2 isoform 2
NM_033120.4	NP_149111.1	protein naked cuticle homolog 2 isoform 1

Protein Preferred Names

Protein Names

protein naked cuticle homolog 2

Dvl-binding protein NKD2

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09318	NKD2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NKD2	VGNC	VGNC:63814
Rattus norvegicus	NKD2	RGD	RGD:1311459
Macaca mulatta	NKD2	VGNC	VGNC:75199
Mus musculus	NKD2	MGD	MGI:1919543
Bos taurus	NKD2	VGNC	VGNC:59353
Canis familiaris	NKD2	VGNC	VGNC:54105