HRG - histidine rich glycoprotein Gene

Homo sapiens

Also known as HPRG; HRGP; THPH11

Gene ID: 3273 | Gene type: protein coding

About HRG

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,666,014-186,678,234 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1677.7).

Summary

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

HRG Products(1)

mRNA	Protein	Name
NM_000412.5	NP_000403.1	histidine-rich glycoprotein precursor

HRG Protein Structure

Cystatin

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

histidine-rich glycoprotein

histidine-proline-rich glycoprotein

Recombinant HRG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77380	HPRG Protein, Human (HEK293, His)	P04196/NP_000403.1 (V19-K525)	≥95%

Related Diseases

Diseases

Alias

Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency

THPH11

Thrombophilia 11 Due To Hrg Deficiency

Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency	Hereditary Thrombophilia Due To Congenital Hrg Deficiency
Thph11

Thrombophilia

Hypercoagulability State

Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency	Proc Deficiency
Congenital Thrombotic Disease, Due To Protein C Deficiency

Thrombosis

Thrombosis Of Blood Vessel

Prothrombin Thrombophilia

Prothrombin G20210a Thrombophilia

Hyperprothrombinemia

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Plasminogen Deficiency, Type I

Hypoplasminogenemia	Dysplasminogenemia
Plasminogen Deficiency Type I	Congenital Plasminogen Deficiency
Ligneous Conjunctivitis	Type 1 Plasminogen Deficiency
Plasminogen Deficiency Type 1	Plasminogen Deficiency
PLGD	Plasminogen Deficiency Type Ii
Deficiency, Plasminogen, Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06358	HRG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HRG	MGD	MGI:2146636
Rattus norvegicus	HRG	RGD	RGD:619808
Macaca mulatta	HRG	VGNC	VGNC:73521
Canis familiaris	HRG	VGNC	VGNC:41785
Felis catus	HRG	VGNC	VGNC:67648
Bos taurus	HRG	VGNC	VGNC:29953
Others	HRG	NCBI