ARHGEF3 - Rho guanine nucleotide exchange factor 3 Gene

Also Known as GEF3; STA3; XPLN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50650

About ARHGEF3

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:56,727,420-57,079,268 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in endometrium (RPKM 17.9), adrenal (RPKM 16.7) and 24 other tissues.

Summary

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone Cell Biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGEF3 Products (13)

mRNA Protein Name
NM_001128615.2 NP_001122087.1 rho guanine nucleotide exchange factor 3 isoform 1
NM_001128616.2 NP_001122088.1 rho guanine nucleotide exchange factor 3 isoform 2
NM_001289698.2 NP_001276627.1 rho guanine nucleotide exchange factor 3 isoform 4
NM_001377407.1 NP_001364336.1 rho guanine nucleotide exchange factor 3 isoform 1
NM_001377408.1 NP_001364337.1 rho guanine nucleotide exchange factor 3 isoform 5
NM_001377409.1 NP_001364338.1 rho guanine nucleotide exchange factor 3 isoform 5
NM_001377410.1 NP_001364339.1 rho guanine nucleotide exchange factor 3 isoform 5
NM_001377411.1 NP_001364340.1 rho guanine nucleotide exchange factor 3 isoform 6
NM_001377412.1 NP_001364341.1 rho guanine nucleotide exchange factor 3 isoform 6
NM_001377413.1 NP_001364342.1 rho guanine nucleotide exchange factor 3 isoform 7
NM_001377414.1 NP_001364343.1 rho guanine nucleotide exchange factor 3 isoform 8
NM_001377415.1 NP_001364344.1 rho guanine nucleotide exchange factor 3 isoform 9
NM_019555.3 NP_062455.1 rho guanine nucleotide exchange factor 3 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF3 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (127 - 302)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 526 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 3

  • 59.8 kDA protein

ARHGEF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARHGEF3 Q9NR81 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra
ARHGEF3 Q9NR81 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra
ARHGEF3 Q9NR81 TERF1 Homo sapiens P54274-2
Y2H Prey Pooling
32296183
Intra
ARHGEF3 Q9NR81 TERF1 Homo sapiens P54274-2
Y2H Array
32296183
Intra
ARHGEF3 Q9NR81 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
ARHGEF3 Q9NR81 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
ARHGEF3 Q9NR81 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
ARHGEF3 Q9NR81 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
ARHGEF3 Q9NR81 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
ARHGEF3 Q9NR81 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
ARHGEF3 Q9NR81 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
ARHGEF3 Q9NR81 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
ARHGEF3 Q9NR81 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
ARHGEF3 Q9NR81 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
ARHGEF3 Q9NR81 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
ARHGEF3 Q9NR81 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
ARHGEF3 Q9NR81 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
ARHGEF3 Q9NR81 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
ARHGEF3 Q9NR81 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Methotrexate-Associated Lymphoproliferation
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00958 ARHGEF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF3 VGNC VGNC:38084
Rattus norvegicus ARHGEF3 RGD RGD:1310672
Macaca mulatta ARHGEF3 VGNC VGNC:70014
Bos taurus ARHGEF3 VGNC VGNC:26115
Felis catus ARHGEF3 VGNC VGNC:68147
Mus musculus ARHGEF3 MGD MGI:1918954
Others ARHGEF3 NCBI