DDA1 - DET1 and DDB1 associated 1 Gene

Also Known as PCIA1; C19orf58

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79016

About DDA1

This gene has 5 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in placenta (RPKM 7.7), brain (RPKM 6.3) and 25 other tissues.

Summary

Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DDA1 Products (1)

mRNA Protein Name
NM_024050.6 NP_076955.1 DET1- and DDB1-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16949367 GOA
Biological Process GO Annotation Evidence References Source
involved in protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
31686031 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16949367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDA1 Protein Structure

DDA1

DDA1: Det1 complexing ubiquitin ligase (3 - 66)

  • 0
  • 102 a.a.
Protein Preferred Names Protein Names

DET1- and DDB1-associated protein 1

  • cross-immune reaction antigen PCIA1

DDA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DDA1 Q9BW61 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra
DDA1 Q9BW61 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra
DDA1 Q9BW61 RDH10 Homo sapiens Q8IZV5
Y2H Prey Pooling
32296183
Intra
DDA1 Q9BW61 RDH10 Homo sapiens Q8IZV5
Y2H Array
32296183
Intra
DDA1 Q9BW61 CMTM5 Homo sapiens Q96DZ9
Y2H Prey Pooling
25416956
Intra
DDA1 Q9BW61 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra
DDA1 Q9BW61 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra
DDA1 Q9BW61 DDB1 Homo sapiens Q16531
Pull Down
30564455
Intra
DDA1 Q9BW61 DDB1 Homo sapiens Q16531
Anti Tag CoIP
20562859
Intra
DDA1 Q9BW61 DDB1 Homo sapiens Q16531
X-Ray Diffraction
30564455
Intra
DDA1 Q9BW61 DDB1 Homo sapiens Q16531
BLI
30564455
Intra
DDA1 Q9BW61 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
Intra
DDA1 Q9BW61 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra
DDA1 Q9BW61 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149441 Indisulam analog-1 / Unkown
HY-156745 DDa-1 Degrader / Unkown
HY-RS03603 DDA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DDA1 VGNC VGNC:102574
Mus musculus DDA1 MGD MGI:1913748
Canis familiaris DDA1 VGNC VGNC:39826
Rattus norvegicus DDA1 RGD RGD:1584153
Macaca mulatta DDA1 VGNC VGNC:71774
Others DDA1 NCBI