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KRT6C - keratin 6C Gene

Also Known as K6E; KRT6E; PPKNEFD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 286887

About KRT6C

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,468,516-52,473,805 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues, 68 paralogues and is associated with 2 phenotypes. Restricted expression toward esophagus (RPKM 948.5).

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]

KRT6C Products (1)

mRNA	Protein	Name
NM_173086.5	NP_775109.2	keratin, type II cytoskeletal 6C

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intermediate filament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23662636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT6C Protein Structure

Filament

0
100
200
300
400
500
564 a.a.

Protein Preferred Names	Protein Names
keratin, type II cytoskeletal 6C	CK-6C

KRT6C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT6C	P48668	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	KRT6C	P48668	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	KRT6C	P48668	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT6C	P48668	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	KRT6C	P48668	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT6C	P48668	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT6C	P48668	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT6C	P48668	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	KRT6C	P48668	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT6C	P48668	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT6C	P48668	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	KRT6C	P48668	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	KRT6C	P48668	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT6C	P48668	KRT26	Homo sapiens	Q7Z3Y9	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT26	Homo sapiens	Q7Z3Y9	Y2H Array	32296183
Intra	KRT6C	P48668	KRT26	Homo sapiens	Q7Z3Y9	Validated Y2H	32296183
Intra	KRT6C	P48668	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	KRT6C	P48668	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	KRT6C	P48668	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	KRT6C	P48668	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	KRT6C	P48668	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	KRT6C	P48668	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KRT6C	P48668	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	KRT6C	P48668	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	KRT6C	P48668	ACTN3	Homo sapiens	Q08043	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT24	Homo sapiens	Q2M2I5	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT24	Homo sapiens	Q2M2I5	Y2H Array	32296183
Intra	KRT6C	P48668	KRT24	Homo sapiens	Q2M2I5	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT18	Homo sapiens	P05783	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT18	Homo sapiens	P05783	Y2H Array	32296183
Intra	KRT6C	P48668	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT6C	P48668	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT6C	P48668	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	KRT6C	P48668	KRT14	Homo sapiens	P02533	Y2H Array	32296183
Intra	KRT6C	P48668	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	KRT6C	P48668	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT6C	P48668	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	KRT6C	P48668	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT6C	P48668	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT6C	P48668	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT6C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81574	Cytokeratin 6 Antibody (YA1319)	WB	Human, Mouse, Rat
HY-P83764	pan Cytokeratin Antibody(YA3563)	WB, IHC-P, mIHC, ICC/IF, IF-Tissue, FC	Human
HY-P85990	Cytokeratin 6 Antibody (YA5682)	IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse	PPKNEFD Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Focal Palmoplantar Keratoderma	Focal Ppk Focal Keratosis Palmoplantaris Focal Palmoplantar Hyperkeratosis
Diffuse Palmoplantar Keratoderma	Diffuse Palmoplantar Hyperkeratosis Diffuse Ppk Diffuse Keratosis Palmoplantaris
Norwegian Scabies	Crusted Scabies Seven Year Itch
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07458	KRT6A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07460	KRT6C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KRT6C	RGD	RGD:1588056