KRT5 - keratin 5 Gene
Also Known as K5; CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; KRT5A
Species: Homo sapiens
About KRT5
This gene has 11 transcripts (splice variants), 108 orthologues, 68 paralogues and is associated with 19 phenotypes. Biased expression in skin (RPKM 2610.9) and esophagus (RPKM 1766.7).
Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
KRT5 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000424.4 | NP_000415.2 | keratin, type II cytoskeletal 5 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10727209 | GOA |
| enables scaffold protein binding |
IPI
IPI: Inferred from physical interaction
|
10852826 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
20128788 | GOA |
| located in intermediate filament |
IDA
IDA: Inferred from direct assay
|
10852826 | GOA |
| located in keratin filament |
IDA
IDA: Inferred from direct assay
|
7679677 | GOA |
KRT5 Protein Structure
Filament: Intermediate filament protein (167 - 480)
- 0
- 100
- 200
- 300
- 400
- 500
- 590 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
keratin, type II cytoskeletal 5 |
|
KRT5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KRT5 | P13647 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT38 | Homo sapiens | O76015 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT38 | Homo sapiens | O76015 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT25 | Homo sapiens | Q7Z3Z0 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT25 | Homo sapiens | Q7Z3Z0 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT25 | Homo sapiens | Q7Z3Z0 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT28 | Homo sapiens | Q7Z3Y7 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT28 | Homo sapiens | Q7Z3Y7 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
KRT5 | P13647 | ALOX12 | Homo sapiens | P18054 | 10727209 | |
|
Intra
|
KRT5 | P13647 | ALOX12 | Homo sapiens | P18054 | 10727209 | |
|
Intra
|
KRT5 | P13647 | ALOX12 | Homo sapiens | P18054 | 10727209 | |
|
Intra
|
KRT5 | P13647 | KIFC3 | Homo sapiens | Q9BVG8 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
KRT5 | P13647 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
KRT5 | P13647 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
KRT5 | P13647 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT14 | Homo sapiens | P02533 | 22705788 | |
|
Intra
|
KRT5 | P13647 | KRT14 | Homo sapiens | P02533 | 22705788 | |
|
Intra
|
KRT5 | P13647 | KRT14 | Homo sapiens | P02533 | 22705788 | |
|
Intra
|
KRT5 | P13647 | KRT14 | Homo sapiens | P02533 | 22705788 | |
|
Intra
|
KRT5 | P13647 | KRT14 | Homo sapiens | P02533 | 22705788 | |
|
Intra
|
KRT5 | P13647 | KRT14 | Homo sapiens | P02533 | 22705788 | |
|
Intra
|
KRT5 | P13647 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT15 | Homo sapiens | P19012 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT15 | Homo sapiens | P19012 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT15 | Homo sapiens | P19012 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
KRT5 | P13647 | PKP1 | Homo sapiens | Q13835-2 | 10852826 | |
|
Intra
|
KRT5 | P13647 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Intra
|
KRT5 | P13647 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
KRT5 | P13647 | KRT31 | Homo sapiens | Q15323 | 32296183 |
KRT5 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80984 | Cytokeratin 5 Antibody (YA3509) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P81268A | Cytokeratin 5 Antibody (YA954) | IHC-P, ICC/IF | Human |
| HY-P84089 | Cytokeratin 5 Antibody (YA3786) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P84089A | Cytokeratin 5 Antibody (YA3786)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P85907 | Cytokeratin 5/6 Antibody (YA5599) | IHC-P, WB, ICC/IF, ELISA | Human |
| HY-P85984 | Cytokeratin 5/6 Antibody (YA5676) | IHC-P, ELISA | Human |
| HY-P86552 | Cytokeratin 5 Antibody (YA6244) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Epidermolysis Bullosa Simplex 2f, With Mottled Pigmentation |
|
|
| Epidermolysis Bullosa Simplex 2e, With Migratory Circinate Erythema |
|
|
| Epidermolysis Bullosa Simplex 2b, Generalized Intermediate |
|
|
| Epidermolysis Bullosa Simplex 2c, Localized |
|
|
| Epidermolysis Bullosa Simplex 2a, Generalized Severe |
|
|
| Dowling-Degos Disease 1 |
|
|
| Epidermolysis Bullosa Simplex 2d, Generalized, Intermediate Or Severe, Autosomal Recessive |
|
|
| Epidermolysis Bullosa Simplex 1a, Generalized Severe |
|
|
| Epidermolysis Bullosa Simplex Localized Type |
|
|
| Epidermolysis Bullosa Simplex |
|
|
| Epidermolysis Bullosa |
|
|
| Epidermolysis Bullosa Simplex Generalized Type |
|
|
| Epidermolysis Bullosa Simplex 1d, Generalized, Intermediate Or Severe, Autosomal Recessive |
|
|
| Epidermolysis Bullosa Simplex 1b, Generalized Intermediate |
|
|
| Epidermolysis Bullosa Simplex 1c, Localized |
|
|
| Dowling-Degos Disease |
|
|
| Epidermolytic Hyperkeratosis |
|
|
| Skin Benign Neoplasm |
|
|
| Sweat Gland Cancer |
|
|
| Basaloid Squamous Cell Carcinoma |
|
|
| Breast Metaplastic Carcinoma |
|
|
| Breast Myoepithelial Neoplasm |
|
|
| Breast Adenomyoepithelioma |
|
|
| Breast Squamous Cell Carcinoma |
|
|
| Adenoid Squamous Cell Carcinoma |
|
|
| Adenosquamous Carcinoma |
|
|
| Sarcomatoid Basal Cell Carcinoma |
|
|
| Benign Mesothelioma |
|
|
| Inverted Transitional Papilloma |
|
|
| Anal Canal Squamous Cell Carcinoma |
|
|
| Testis Sarcoma |
|
|
| Intraductal Breast Benign Neoplasm |
|
|
| Lymphoepithelioma-Like Carcinoma |
|
|
| Keratinizing Squamous Cell Carcinoma |
|
|
| Inverted Papilloma |
|
|
| Nasal Cavity Cancer |
|
|
| Papilloma |
|
|
| Breast Intraductal Proliferative Lesion |
|
|
| Malignant Biphasic Mesothelioma |
|
|
| Ceruminous Adenocarcinoma |
|
|
| Esophageal Adenosquamous Carcinoma |
|
|
| Adenosquamous Breast Carcinoma |
|
|
| Sarcomatoid Mesothelioma |
|
|
| Large Cell Carcinoma |
|
|
| Sweat Gland Disease |
|
|
| Pregnancy Adenoma |
|
|
| Reticulate Acropigmentation Of Kitamura |
|
|
| Salivary Gland Carcinoma |
|
|
| Sebaceous Adenocarcinoma |
|
|
| Trachea Carcinoma |
|
|
| Rectum Squamous Cell Carcinoma |
|
|
| Gastric Squamous Cell Carcinoma |
|
|
| Spermatic Cord Cancer |
|
|
| Benign Peritoneal Mesothelioma |
|
|
| Pericardium Cancer |
|
|
| Pericardial Mesothelioma |
|
|
| Lung Clear Cell Carcinoma |
|
|
| Micronodular Basal Cell Carcinoma |
|
|
| Nodular Hidradenoma |
|
|
| Intraductal Papilloma |
|
|
| Ichthyosis |
|
|
| Palmoplantar Keratosis |
|
|
| Thymus Basaloid Carcinoma |
|
|
| Apocrine Sweat Gland Neoplasm |
|
|
| Peritoneal Mesothelioma |
|
|
| Ceruminoma |
|
|
| Bullous Pemphigoid |
|
|
| Myoepithelial Carcinoma |
|
|
| Benign Breast Adenomyoepithelioma |
|
|
| Intracystic Papillary Adenoma |
|
|
| Frontal Sinus Inverted Papilloma |
|
|
| Clear Cell Basal Cell Carcinoma |
|
|
| Epithelial-Myoepithelial Carcinoma |
|
|
| Penile Urethral Cancer |
|
|
| Sarcomatoid Squamous Cell Skin Carcinoma |
|
|
| Breast Carcinoma In Situ |
|
|
| Pre-Malignant Neoplasm |
|
|
| Papillary Adenoma |
|
|
| Frontal Sinus Benign Neoplasm |
|
|
| Anal Canal Carcinoma |
|
|
| Keratosis |
|
|
| Cloacogenic Carcinoma |
|
|
| Apocrine Adenocarcinoma |
|
|
| Breast Malignant Phyllodes Tumor |
|
|
| Thymus Large Cell Carcinoma |
|
|
| Subareolar Duct Papillomatosis |
|
|
| Nipple Benign Neoplasm |
|
|
| Tibial Adamantinoma |
|
|
| Balloon Cell Malignant Melanoma |
|
|
| Adamantinoma Of Long Bones |
|
|
| Eccrine Papillary Adenocarcinoma |
|
|
| Eccrine Adenocarcinoma |
|
|
| Breast Mucoepidermoid Carcinoma |
|
|
| Basaloid Lung Carcinoma |
|
|
| Sweat Gland Benign Neoplasm |
|
|
| Thoracic Benign Neoplasm |
|
|
| Breast Benign Neoplasm |
|
|
| Peritoneum Cancer |
|
|
| Breast Ductal Carcinoma |
|
|
| Cervix Erosion |
|
|
| Breast Adenoid Cystic Carcinoma |
|
|
| Spindle Cell Thymoma |
|
|
| Odontoma |
|
|
| Ductal Carcinoma In Situ |
|
|
| Eccrine Sweat Gland Cancer |
|
|
| Malignant Syringoma |
|
|
| Necrotizing Sialometaplasia |
|
|
| Breast Papillary Carcinoma |
|
|
| Breast Cancer |
|
|
| Pleomorphic Carcinoma |
|
|
| In Situ Carcinoma |
|
|
| Skin Disease |
|
|
| Hidradenoma |
|
|
| Benign Teratoma |
|
|
| Cribriform Carcinoma |
|
|
| Vulvar Sebaceous Carcinoma |
|
|
| Bile Duct Mucoepidermoid Carcinoma |
|
|
| Lung Leiomyosarcoma |
|
|
| Breast Lobular Carcinoma |
|
|
| Syringocystadenoma Papilliferum |
|
|
| Female Breast Cancer |
|
|
| Prostatic Urethral Cancer |
|
|
| Malignant Acrospiroma |
|
|
| Eccrine Sweat Gland Neoplasm |
|
|
| Comedo Carcinoma |
|
|
| Laryngeal Adenoid Cystic Carcinoma |
|
|
| Breast Secretory Carcinoma |
|
|
| Craniopharyngioma |
|
|
| Middle Ear Adenoma |
|
|
| Breast Sarcoma |
|
|
| Auditory System Benign Neoplasm |
|
|
| Lymphoepithelioma-Like Thymic Carcinoma |
|
|
| Hypotrichosis |
|
|
| Mucoepidermoid Esophageal Carcinoma |
|
|
| Lipid-Rich Carcinoma |
|
|
| Eccrine Acrospiroma |
|
|
| Sinonasal Undifferentiated Carcinoma |
|
|
| Microinvasive Cervical Squamous Cell Carcinoma |
|
|
| Anus Basaloid Carcinoma |
|
|
| Malignant Spiradenoma |
|
|
| Clear Cell Hidradenoma |
|
|
| Rete Testis Neoplasm |
|
|
| Rete Testis Adenocarcinoma |
|
|
| Tonsil Cancer |
|
|
| Borst-Jadassohn Intraepidermal Carcinoma |
|
|
| Lipoadenoma |
|
|
| Basal Cell Carcinoma |
|
|
| Eccrine Porocarcinoma |
|
|
| Solid Adenocarcinoma With Mucin Production |
|
|
| Adenomatoid Tumor |
|
|
| Breast Mucinous Carcinoma |
|
|
| Corneal Dystrophy |
|
|
| Parietal Lobe Neoplasm |
|
|
| Adenosquamous Gallbladder Carcinoma |
|
|
| Spiradenoma |
|
|
| Adult Type Testicular Granulosa Cell Tumor |
|
|
| Ureter Squamous Cell Carcinoma |
|
|
| Vulvar Apocrine Adenocarcinoma |
|
|
| Esophageal Neuroendocrine Tumor |
|
|
| Paranasal Sinus Cancer |
|
|
| Tracheal Cancer |
|
|
| Proliferative Type Fibrocystic Change Of Breast |
|
|
| Lung Large Cell Carcinoma |
|
|
| Lipid-Rich Breast Carcinoma |
|
|
| Lobular Neoplasia |
|
|
| Lung Sarcomatoid Carcinoma |
|
|
| Skin Carcinoma |
|
|
| Clear Cell Acanthoma |
|
|
| Papillary Squamous Carcinoma |
|
|
| Combined Thymoma |
|
|
| Mixed Cell Type Cancer |
|
|
| Cutaneous Leiomyosarcoma |
|
|
| Bullous Skin Disease |
|
|
| Paget Disease, Extramammary |
|
|
| Heart Cancer |
|
|
| Sublingual Gland Adenoid Cystic Carcinoma |
|
|
| External Ear Carcinoma |
|
|
| Lung Giant Cell Carcinoma |
|
|
| Vulva Basal Cell Carcinoma |
|
|
| Salivary Gland Disease |
|
|
| Cystic Basal Cell Carcinoma |
|
|
| Large Cell Neuroendocrine Carcinoma |
|
|
| Male Urethral Cancer |
|
|
| Sensory Organ Benign Neoplasm |
|
|
| Ureter Adenocarcinoma |
|
|
| Salivary Gland Adenoid Cystic Carcinoma |
|
|
| Psoriasis |
|
|
| Cutaneous Mucoepidermoid Carcinoma |
|
|
| Nasal Cavity Olfactory Neuroblastoma |
|
|
| Oropharynx Cancer |
|
|
| Pachyonychia Congenita 1 |
|
|
| Cicatricial Lagophthalmos |
|
|
| Hypertrophy Of Breast |
|
|
| Renal Pelvis Squamous Cell Carcinoma |
|
|
| Epidermolysis Bullosa Dystrophica |
|
|
| Acanthoma |
|
|
| Hair Follicle Neoplasm |
|
|
| Dyschromatosis Universalis Hereditaria |
|
|
| Testicular Fibroma |
|
|
| Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia |
|
|
| Large Cell Acanthoma |
|
|
| Junctional Epidermolysis Bullosa |
|
|
| Papillary Adenocarcinoma |
|
|
| Sublingual Gland Cancer |
|
|
| Mediastinal Cancer |
|
|
| Liver Fibroma |
|
|
| Breast Myoepithelial Carcinoma |
|
|
| Sporadic Breast Cancer |
|
|
| Thymic Carcinoma |
|
|
| Palmoplantar Keratoderma, Epidermolytic |
|
|
| Keratosis, Seborrheic |
|
|
| Small Cell Carcinoma |
|
|
| Breast Fibroadenoma |
|
|
| Cystic Teratoma |
|
|
| Breast Adenoma |
|
|
| Prostate Cancer |
|
|
| Pleural Cancer |
|
|
| Primary Cutaneous Amyloidosis |
|
|
| Nephrogenic Adenoma Of The Urethra |
|
|
| Squamous Cell Bile Duct Carcinoma |
|
|
| Metatypical Basal Cell Carcinoma |
|
|
| Verrucous Carcinoma |
|
|
| Respiratory System Benign Neoplasm |
|
|
| Laryngeal Small Cell Carcinoma |
|
|
| Epididymis Adenocarcinoma |
|
|
| Ureter Small Cell Carcinoma |
|
|
| Skin Squamous Cell Carcinoma |
|
|
| Epididymis Cancer |
|
|
| Thymus Gland Disease |
|
|
| Pilomatrixoma |
|
|
| Thymus Cancer |
|
|
| Middle Ear Adenocarcinoma |
|
|
| Mesothelioma, Malignant |
|
|
| Prostate Signet Ring Cell Adenocarcinoma |
|
|
| Pleural Disease |
|
|
| Vulvar Proximal-Type Epithelioid Sarcoma |
|
|
| Central Epithelioid Sarcoma |
|
|
| Urethral Benign Neoplasm |
|
|
| Breast Adenocarcinoma |
|
|
| Transient Bullous Dermolysis Of The Newborn |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Breast Leiomyosarcoma |
|
|
| Lymphohistiocytoid Mesothelioma |
|
|
| Endobronchial Lipoma |
|
|
| Synchronous Bilateral Breast Carcinoma |
|
|
| Wilms Tumor 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | KRT5 | RGD | RGD:727894 |
| Bos taurus | KRT5 | VGNC | VGNC:50405 |
| Mus musculus | KRT5 | MGD | MGI:96702 |
| Others | KRT5 | NCBI |