Cytokeratin 5 Antibody (YA954)
(Synonyms: 58 kDa cytokeratin; CK 5; CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS 2; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5)Cytokeratin 5 Antibody (YA954) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in Ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:100-1:200 | 1:50-1:200 |
Product Details
Cytokeratin 5 Antibody (YA954) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 62 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 62 kDa
Purified recombinant fragment of CK5 expressed in E. Coli.
Endogenous
Ascitic Fluid
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Ascitic fluid containing 0.03% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cytokeratin 5 is required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes
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Subcellular Localization
Cytoplasm
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Expression
Tissue_specificity:Expression (protein level) in corneal epithelial cells (PubMed: 26758872) . Expression (protein level) in keratinocytes (PubMed: 20128788, PubMed: 31302245) . -
Subunit
Heterodimer of a type I and a type II keratin (PubMed:22705788, PubMed:31995743). Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network (PubMed:28899683). Forms a heterodimer (via 2B domains) with KRT14 (via 2B domains) (PubMed:22705788, PubMed:24940650, PubMed:31995743). Interacts with PLEC isoform 1C, when in a heterodimer with KRT14 (PubMed:24940650). Interacts with TCHP (PubMed:15731013). Interacts with EPPK1 (By similarity). Interacts with AMELX (By similarity). Interacts with PKP1 (via N-terminus) and PKP2 (PubMed:10852826)
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SwissProt ID
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Synonyms
58 kDa cytokeratin; CK 5; CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS 2; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5
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Research Field
Signal Transduction
Documentation
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