EVL - Enah/Vasp-like Gene

Also Known as RNB6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51466

About EVL

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,971,422-100,144,236 (from NCBI)

This gene has 24 transcripts (splice variants), 264 orthologues and 5 paralogues. Broad expression in lymph node (RPKM 31.5), spleen (RPKM 27.6) and 24 other tissues.

Summary

Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

EVL Products (2)

mRNA Protein Name
NM_001330221.2 NP_001317150.1 ena/VASP-like protein isoform 2
NM_016337.3 NP_057421.1 ena/VASP-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10993894 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
23153535 GOA
involved in negative regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
23153535 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
23153535 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EVL Protein Structure

WH1

WH1: WH1 domain (4 - 105)

VASP_tetra

VASP_tetra: VASP tetramerisation domain (376 - 415)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

ena/VASP-like protein

  • ena/vasodilator-stimulated phosphoprotein-like

EVL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EVL Q9UI08 SPTAN1 Homo sapiens Q13813
Anti Tag CoIP
16336193
Intra
EVL Q9UI08 SPTAN1 Homo sapiens Q13813
Y2H
16336193
Intra
EVL Q9UI08 TRIM9 Homo sapiens Q9C026
Validated Y2H
25416956
Intra
EVL Q9UI08 ABI3 Homo sapiens Q9P2A4
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastrointestinal Adenoma

  • Gi Adenoma

  • Digestive System Adenoma
Myasthenic Syndrome, Congenital, 10

  • Congenital Myasthenic Syndrome 10

  • CMS10

  • Lgm

  • Myasthenia, Limb-Girdle, Familial

  • Myasthenia, Limb-Girdle, Familial, Formerly

  • Lgm, Formerly

  • Congenital Myasthenic Syndrome Type Ib, Formerly

  • Cms1b, Formerly

  • Cms Ib, Formerly

  • Myasthenic Myopathy, Formerly

  • Familial Limb-Girdle Myasthenia

  • Cms1b

  • Cms Ib

  • Congenital Myasthenic Syndrome Type 1b

  • Congenital Myasthenic Syndrome Type Ib

  • Myasthenic Myopathy

  • Myasthenic Syndrome, Congenital, Type 10

  • Congenital Myasthenic Syndrome Ib

  • Myopathy In Myasthenia Gravis
Drug-Induced Lupus Erythematosus

  • Dile

  • Dil

  • Drug-Induced Systemic Lupus Erythematosus
Frontometaphyseal Dysplasia

  • Fmd

  • Dysplasia, Frontometaphyseal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04577 EVL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21283 Evl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27802 Evl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EVL RGD RGD:621150
Bos taurus EVL VGNC VGNC:28636
Canis familiaris EVL VGNC VGNC:40505
Felis catus EVL VGNC VGNC:61991
Mus musculus EVL MGD MGI:1194884
Macaca mulatta EVL VGNC VGNC:72306
Others EVL NCBI