RUFY3 - RUN and FYVE domain containing 3 Gene

Also Known as RIPX; SINGAR1; ZFYVE30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22902

About RUFY3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,703,767-70,808,619 (from NCBI)

This gene has 15 transcripts (splice variants), 215 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 27.2), testis (RPKM 10.8) and 24 other tissues.

Summary

This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric Cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

RUFY3 Products (6)

mRNA Protein Name
NM_001037442.4 NP_001032519.1 protein RUFY3 isoform 1
NM_001130709.2 NP_001124181.1 protein RUFY3 isoform 3
NM_001291993.2 NP_001278922.1 protein RUFY3 isoform 4
NM_001291994.2 NP_001278923.1 protein RUFY3 isoform 5
NM_001345840.2 NP_001332769.1 protein RUFY3 isoform 6
NM_014961.5 NP_055776.1 protein RUFY3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
25766321 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
25766321 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25766321 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RUFY3 Protein Structure

RUN

RUN: RUN domain (103 - 225)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

protein RUFY3

  • rap2 interacting protein x

RUFY3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RUFY3 Q7L099 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05173 FYCO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12345 RUFY3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RUFY3 VGNC VGNC:45805
Macaca mulatta RUFY3 VGNC VGNC:77128
Bos taurus RUFY3 VGNC VGNC:34215
Rattus norvegicus RUFY3 RGD RGD:1565242
Mus musculus RUFY3 MGD MGI:106484
Felis catus RUFY3 VGNC VGNC:64820
Others RUFY3 NCBI