2. Gene
  3. FARSA - phenylalanyl-tRNA synthetase subunit alpha Gene

FARSA - phenylalanyl-tRNA synthetase subunit alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FRSA; CML33; FARSL; PheHA; FARSLA; RILDBC2

Gene ID: 2193 | Gene type: protein coding

About FARSA

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,922,479-12,933,711 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 24.2), lymph node (RPKM 16.8) and 25 other tissues.

Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate Amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

FARSA Products(1)

mRNA Protein Name
NM_004461.3 NP_004452.1 phenylalanine--tRNA ligase alpha subunit

FARSA Protein Structure

tRNA-synt_2d

tRNA-synt_2d: tRNA synthetases class II core domain (F) (210 - 483)

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  • 508 a.a.
Protein Preferred Names Protein Names

phenylalanine--tRNA ligase alpha subunit

pheRS

Related Diseases

Diseases Alias
Rajab Interstitial Lung Disease With Brain Calcifications 2

RILDBC2
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases
Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04749 FARSA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FARSA RGD RGD:1310314
Macaca mulatta FARSA VGNC VGNC:72615
Felis catus FARSA VGNC VGNC:62151
Mus musculus FARSA MGD MGI:1913840
Bos taurus FARSA VGNC VGNC:28867
Canis familiaris FARSA VGNC VGNC:40733