FARSB - phenylalanyl-tRNA synthetase subunit beta Gene

Also Known as FRSB; PheHB; PheRS; FARSLB; RILDBC; HSPC173; NEDBLLA; RILDBC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10056

About FARSB

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:222,566,899-222,656,092 (from NCBI)

This gene has 2 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 8.3), testis (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a highly conserved enzyme that belongs to the Aminoacyl-tRNA Synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

FARSB Products (1)

mRNA	Protein	Name
NM_005687.5	NP_005678.3	phenylalanine--tRNA ligase beta subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phenylalanine-tRNA ligase activity	IDA IDA: Inferred from direct assay	20223217	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20223217	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phenylalanyl-tRNA aminoacylation	IDA IDA: Inferred from direct assay	20223217	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	20223217	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of phenylalanine-tRNA ligase complex	IDA IDA: Inferred from direct assay	20223217	GOA
part of phenylalanine-tRNA ligase complex	IPI IPI: Inferred from physical interaction	20223217	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FARSB Protein Structure

B3_4

B5

0
100
200
300
400
500
589 a.a.

Protein Preferred Names	Protein Names
phenylalanine--tRNA ligase beta subunit	phenylalanine tRNA ligase 1, beta, cytoplasmic

FARSB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FARSB	Q9NSD9	FARSA	Homo sapiens	Q9Y285	Anti Tag CoIP	33961781
Intra	FARSB	Q9NSD9	FARSA	Homo sapiens	Q9Y285	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Rajab Interstitial Lung Disease With Brain Calcifications 1	Rajab Interstitial Lung Disease With Brain Calcifications Rajab Syndrome RILDBC1 Rildbc Developmental Delay, Small Stature, Microcephaly, And Brain Calcifications, Formerly Neurodevelopmental Disorder With Brain, Liver, And Lung Abnormalities, Formerly Nedblla, Formerly Developmental Delay, Small Stature, Microcephaly, And Brain Calcifications Nedblla Neurodevelopmental Disorder With Brain, Liver, And Lung Abnormalities
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Brain Calcification, Rajab Type
Interstitial Lung And Liver Disease	Severe Early-Onset Pulmonary Alveolar Proteinosis Due To Mars Deficiency ILLD Pulmonary Alveolar Proteinosis, Reunion Island Infantile Liver Failure Syndrome 2 Infantile Liver Failure Syndrome 2, Formerly Ilfs2, Formerly Hereditary Pulmonary Alveolar Proteinosis With Hepatic Involvement Pap, Reunion Island Type Pulmonary Alveolar Proteinosis, Reunion Island Type Ilfs2 Lung And Liver Disease, Interstitial
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Niemann-Pick Disease, Type C2	NPC2 Niemann-Pick Disease Type C2 Niemann-Pick C2 Disease Niemann-Pick Disease C2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04750	FARSB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FARSB	RGD	RGD:1303210
Macaca mulatta	FARSB	VGNC	VGNC:72522
Mus musculus	FARSB	MGD	MGI:1346035
Felis catus	FARSB	VGNC	VGNC:80210
Bos taurus	FARSB	VGNC	VGNC:28868
Canis familiaris	FARSB	VGNC	VGNC:97196
Others	FARSB	NCBI