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TACC3 - transforming acidic coiled-coil containing protein 3 Gene

Also Known as ERIC1; Tacc4; ERIC-1; maskin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10460

About TACC3

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,721,521-1,745,171 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 25.6), bone marrow (RPKM 24.9) and 16 other tissues.

Summary

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain Cancer cells. [provided by RefSeq, Nov 2011]

TACC3 Products (2)

mRNA	Protein	Name
NM_001410699.1	NP_001397628.1	transforming acidic coiled-coil-containing protein 3 isoform 2
NM_006342.3	NP_006333.1	transforming acidic coiled-coil-containing protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20360068	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in metaphase/anaphase transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23532825	GOA
involved in microtubule cytoskeleton organization involved in mitosis	IMP IMP: Inferred from mutant phenotype	23532825	GOA
involved in regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	21297582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACC3 Protein Structure

TACC

0
200
400
600
800
838 a.a.

Protein Preferred Names	Protein Names
transforming acidic coiled-coil-containing protein 3

TACC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Array	32296183
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Prey Pooling	32296183
Intra	TACC3	Q9Y6A5	CLTA	Homo sapiens	P09496	Anti Bait CoIP	21297582
Intra	TACC3	Q9Y6A5	ASPSCR1	Homo sapiens	Q9BZE9	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	ASPSCR1	Homo sapiens	Q9BZE9	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	IQCD	Homo sapiens	Q96DY2-2	Y2H Array	32296183
Intra	TACC3	Q9Y6A5	IQCD	Homo sapiens	Q96DY2-2	Y2H Prey Pooling	32296183
Intra	TACC3	Q9Y6A5	VPS37C	Homo sapiens	A5D8V6	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	VPS37C	Homo sapiens	A5D8V6	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	EGFR	Homo sapiens	P00533	Ub Reconstruction	27956147
Intra	TACC3	Q9Y6A5	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27956147
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Anti Tag CoIP	33961781
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	IF	21297582
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Anti Tag CoIP	26496610
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Biochemical	21297582
Intra	TACC3	Q9Y6A5	SNX20	Homo sapiens	Q7Z614	Y2H Prey Pooling	25416956
Intra	TACC3	Q9Y6A5	SNX20	Homo sapiens	Q7Z614	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	Y2H	27107012
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	Anti Tag CoIP	33961781
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	SLC	27107012
Intra	TACC3	Q9Y6A5	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012
Intra	TACC3	Q9Y6A5	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TACC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83176	TACC3 Antibody (YA2921)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Developmental And Epileptic Encephalopathy 23	DEE23 Epileptic Encephalopathy, Early Infantile, 23 Eiee23 Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome Epilepsy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome Developmental And Epileptic Encephalopathy, 23 Early Infantile Epileptic Encephalopathy 23
Thymus Lymphoma	Thymic Lymphoma
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172158	ALKBH5-IN-5		99.66%	Unkown
HY-135960	BO-264		99.76%	Unkown
HY-10996A	KHS101 hydrochloride		99.65%	Unkown
HY-120087	KG-548	Inhibitor	99.90%	Unkown
HY-111876	SNIPER(TACC3)-1		98.67%	Unkown
HY-111877	SNIPER(TACC3)-2		99.54%	Unkown
HY-145895	SNIPER(TACC3)-11	Inhibitor	99.58%	Unkown
HY-W012248	KG-655	Inhibitor	99.87%	Unkown
HY-174981	LC-MF-4		98.05%	Unkown
HY-10996	KHS101		/	Unkown
HY-111876A	SNIPER(TACC3)-1 hydrochloride		/	Unkown
HY-111877A	SNIPER(TACC3)-2 hydrochloride		/	Unkown
HY-111886	KHS108-MV1		/	Unkown
HY-112500	Spindlactone B		/	Unkown
HY-151985	TACC3 inhibitor 1	Inducer	/	Unkown
HY-170960	TACC3 inhibitor 2		/	Unkown
HY-186208	TACC3-IN-3		/	Unkown
HY-186209	TACC3-IN-4		/	Unkown
HY-186210	TACC3-IN-5		/	Unkown
HY-RS14141	TACC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16930	Tacc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23373	Tacc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TACC3	VGNC	VGNC:53244
Bos taurus	TACC3	VGNC	VGNC:53778
Macaca mulatta	TACC3	VGNC	VGNC:78082
Rattus norvegicus	TACC3	RGD	RGD:1302948
Mus musculus	TACC3	MGD	MGI:1341163
Felis catus	TACC3	VGNC	VGNC:82312
Others	TACC3	NCBI