2. Apoptosis
  3. Apoptosis
  4. TACC3 inhibitor 1

TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity.

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TACC3 inhibitor 1

TACC3 inhibitor 1 Chemical Structure

CAS No. : 3033646-06-6

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TACC3 inhibitor 1 Related Antibodies

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Description

TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity[1].

Cellular Effect
Cell Line Type Value Description References
JIMT-1 IC50
4.84 μM
Compound: 7g
Antiproliferative activity against human JIMT-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human JIMT-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 36332551]
MDA-MB-231 IC50
6.46 μM
Compound: 7g
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 36332551]
SK-OV-3 IC50
8.21 μM
Compound: 7g
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 36332551]
U-251 IC50
5.61 μM
Compound: 7g
Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 36332551]
U-87MG ATCC IC50
27.54 μM
Compound: 7g
Cytotoxicity against human U87 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 36332551]
U-87MG ATCC IC50
3.29 μM
Compound: 7g
Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36332551]
In Vitro

TACC3 inhibitor 1 (compound 7g) (1, 2, 4 µM; 36 h) induces apoptosis and cell cycle arrest at G2/M phase[1].
TACC3 inhibitor 1 (1, 2, 4 µM; 36 h) decreases the mitochondrial membrane potential and induces the generation of intracellular ROS[1].
TACC3 inhibitor 1 (1, 2, 4 µM; 24 h) inhibits cell migration and invasion in U87 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TACC3 inhibitor 1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Showed antiproliferative activities with IC50s of 5.61, 3.29, 6.46, 4.84, 8.21, 23.11 µM for U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced cell cycle arrest at G2/M phase with the 41.2% cells at G2/M phase at 4 µM.

Apoptosis Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced apoptosis in a dose-dependent manner with the percentage of early apoptotic cells increased from 4.49% in control group to 21.42%, late apoptotic cells increased from 0.52% to 26.72% at 4 µM.
In Vivo

TACC3 inhibitor 1 (20 mg/kg; i.p.; daily for 20 days) shows anti-tumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old BALB/c nude mice (U87 xenograft model)[1]
Dosage: 20 mg/kg
Administration: I.p.; daily for 20 days
Result: Exhibited a significant tumor growth regression and no observable toxicity during the administration period and had no effects on the body weight.
Molecular Weight

379.48

Formula

C20H21N5OS
CAS No.
SMILES

OC1CC2CC1CN2C3=CC=NC(NCC4=CSC(C5=CC=CC=C5)=N4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TACC3 inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TACC3 inhibitor 13033646-06-6Apoptosiscross the blood-brain barrierantiproliferativeanti-tumorapoptosisG2/M phasemigrationinvasionU87 cellsInhibitorinhibitorinhibit

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