2. Apoptosis
  3. Apoptosis
  4. TACC3 inhibitor 1

TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity.

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TACC3 inhibitor 1 Chemical Structure

TACC3 inhibitor 1 Chemical Structure

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TACC3 inhibitor 1 Related Antibodies

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Description

TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity[1].

In Vitro

TACC3 inhibitor 1 (compound 7g) (1, 2, 4 µM; 36 h) induces apoptosis and cell cycle arrest at G2/M phase[1].
TACC3 inhibitor 1 (1, 2, 4 µM; 36 h) decreases the mitochondrial membrane potential and induces the generation of intracellular ROS[1].
TACC3 inhibitor 1 (1, 2, 4 µM; 24 h) inhibits cell migration and invasion in U87 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TACC3 inhibitor 1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Showed antiproliferative activities with IC50s of 5.61, 3.29, 6.46, 4.84, 8.21, 23.11 µM for U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced cell cycle arrest at G2/M phase with the 41.2% cells at G2/M phase at 4 µM.

Apoptosis Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced apoptosis in a dose-dependent manner with the percentage of early apoptotic cells increased from 4.49% in control group to 21.42%, late apoptotic cells increased from 0.52% to 26.72% at 4 µM.
In Vivo

TACC3 inhibitor 1 (20 mg/kg; i.p.; daily for 20 days) shows anti-tumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old BALB/c nude mice (U87 xenograft model)[1]
Dosage: 20 mg/kg
Administration: I.p.; daily for 20 days
Result: Exhibited a significant tumor growth regression and no observable toxicity during the administration period and had no effects on the body weight.
Molecular Weight

379.48

Formula

C20H21N5OS
SMILES

OC1CC2CC1CN2C3=CC=NC(NCC4=CSC(C5=CC=CC=C5)=N4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TACC3 inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TACC3 inhibitor 1Apoptosiscross the blood-brain barrierantiproliferativeanti-tumorapoptosisG2/M phasemigrationinvasionU87 cellsInhibitorinhibitorinhibit

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