SNIPER(TACC3)-11
Based on 1 Customer Validation
SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells.
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- Pureté : 99.58%
- CAS No.: 2906151-68-4
- Formule: C51H66N10O7S2
- Masse moléculaire:995.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
FGFR3-TACC3[1]
In Vitro
SNIPER(TACC3)-11 (compound 5a) (0.3-3 μM; 6 hours) reduces FGFR3-TACC3 levels[1].
SNIPER(TACC3)-11 (0.3-3 μM; 72 hours) inhibits the growth of RT4 cells at 3 µM, and does not inhibit the growth of HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RT4 cells[1]
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Concentration:0.3, 1 and 3 μM
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Incubation Time:6 hours
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Result:Reduced FGFR3-TACC3 levels.
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Cell Line:RT4 and HeLa cells[1]
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Concentration:0.3, 1 and 3 μM
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Incubation Time:72 hours
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Result:Dramatically inhibited the growth of RT4 cells at 3 µM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3.
Chemical Information
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CAS No. 2906151-68-4
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Appearance Solid
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Masse moléculaire 995.26
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Formule C51H66N10O7S2
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Color White to off-white
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SMILES
CN[C@H](C(N[C@@H](C1CCCCC1)C(N2CCC[C@H]2C3=NC(C(C4=CC(OCCOCCOCCNC(C5=CC=C(C=C5)C6=NC(CNC7=NC=CC(NCC(C)C)=N7)=CS6)=O)=CC=C4)=O)=CS3)=O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (100.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0048 mL | 5.0238 mL | 10.0476 mL | 25.1191 mL |
| 5 mM | 0.2010 mL | 1.0048 mL | 2.0095 mL | 5.0238 mL | |
| 10 mM | 0.1005 mL | 0.5024 mL | 1.0048 mL | 2.5119 mL | |
| 15 mM | 0.0670 mL | 0.3349 mL | 0.6698 mL | 1.6746 mL | |
| 20 mM | 0.0502 mL | 0.2512 mL | 0.5024 mL | 1.2560 mL | |
| 25 mM | 0.0402 mL | 0.2010 mL | 0.4019 mL | 1.0048 mL | |
| 30 mM | 0.0335 mL | 0.1675 mL | 0.3349 mL | 0.8373 mL | |
| 40 mM | 0.0251 mL | 0.1256 mL | 0.2512 mL | 0.6280 mL | |
| 50 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5024 mL | |
| 60 mM | 0.0167 mL | 0.0837 mL | 0.1675 mL | 0.4187 mL | |
| 80 mM | 0.0126 mL | 0.0628 mL | 0.1256 mL | 0.3140 mL | |
| 100 mM | 0.0100 mL | 0.0502 mL | 0.1005 mL | 0.2512 mL |
SNIPER(TACC3)-11 Related Classifications
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