2. Protein Tyrosine Kinase/RTK PROTAC
  3. FGFR SNIPERs
  4. SNIPER(TACC3)-11

SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells.

For research use only. We do not sell to patients.

SNIPER(TACC3)-11 Chemical Structure

SNIPER(TACC3)-11 Chemical Structure

CAS No. : 2906151-68-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 3361 In-stock
Solution
10 mM * 1 mL in DMSO USD 3361 In-stock
Solid
1 mg USD 700 In-stock
5 mg USD 1805 In-stock
10 mg USD 3070 In-stock
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Based on 1 publication(s) in Google Scholar

SNIPER(TACC3)-11 Related Antibodies

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Description

SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells[1].

IC50 & Target

FGFR3-TACC3[1]
In Vitro

SNIPER(TACC3)-11 (compound 5a) (0.3-3 μM; 6 hours) reduces FGFR3-TACC3 levels[1].
SNIPER(TACC3)-11 (0.3-3 μM; 72 hours) inhibits the growth of RT4 cells at 3 µM, and does not inhibit the growth of HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SNIPER(TACC3)-11 Related Antibodies

Western Blot Analysis

Cell Line: RT4 cells[1]
Concentration: 0.3, 1 and 3 μM
Incubation Time: 6 hours
Result: Reduced FGFR3-TACC3 levels.

Cell Proliferation Assay

Cell Line: RT4 and HeLa cells[1]
Concentration: 0.3, 1 and 3 μM
Incubation Time: 72 hours
Result: Dramatically inhibited the growth of RT4 cells at 3 µM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3.
Molecular Weight

995.26

Formula

C51H66N10O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN[C@H](C(N[C@@H](C1CCCCC1)C(N2CCC[C@H]2C3=NC(C(C4=CC(OCCOCCOCCNC(C5=CC=C(C=C5)C6=NC(CNC7=NC=CC(NCC(C)C)=N7)=CS6)=O)=CC=C4)=O)=CS3)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (100.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0048 mL 5.0238 mL 10.0476 mL
5 mM 0.2010 mL 1.0048 mL 2.0095 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0048 mL 5.0238 mL 10.0476 mL 25.1191 mL
5 mM 0.2010 mL 1.0048 mL 2.0095 mL 5.0238 mL
10 mM 0.1005 mL 0.5024 mL 1.0048 mL 2.5119 mL
15 mM 0.0670 mL 0.3349 mL 0.6698 mL 1.6746 mL
20 mM 0.0502 mL 0.2512 mL 0.5024 mL 1.2560 mL
25 mM 0.0402 mL 0.2010 mL 0.4019 mL 1.0048 mL
30 mM 0.0335 mL 0.1675 mL 0.3349 mL 0.8373 mL
40 mM 0.0251 mL 0.1256 mL 0.2512 mL 0.6280 mL
50 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5024 mL
60 mM 0.0167 mL 0.0837 mL 0.1675 mL 0.4187 mL
80 mM 0.0126 mL 0.0628 mL 0.1256 mL 0.3140 mL
100 mM 0.0100 mL 0.0502 mL 0.1005 mL 0.2512 mL
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SNIPER(TACC3)-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNIPER(TACC3)-112906151-68-4FGFRSNIPERsFibroblast growth factor receptorIAP-dependent Protein Eraser, Specific and Nongenetic inhibitor of apoptosis protein [IAP]-dependent Protein ErasersFGFR3-TACC3 positiveRT4 cellsCell proliferationAnticancerInhibitorinhibitorinhibit

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