TRAFD1 - TRAF-type zinc finger domain containing 1 Gene

Also Known as FLN29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10906

About TRAFD1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,125,560-112,153,604 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 18.8), lymph node (RPKM 16.4) and 25 other tissues.

Summary

The innate immune system confers host defense against viral and microbial Infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

TRAFD1 Products (2)

mRNA Protein Name
NM_001143906.2 NP_001137378.1 TRAF-type zinc finger domain-containing protein 1
NM_006700.3 NP_006691.1 TRAF-type zinc finger domain-containing protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TRAF-type zinc finger domain-containing protein 1

  • FLN29 gene product

TRAFD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRAFD1 O14545 HTT Homo sapiens P42858
Y2H Prey Pooling
23275563
Intra
TRAFD1 O14545 HTT Homo sapiens P42858
Y2H
17500595
Intra
TRAFD1 O14545 NGLY1 Homo sapiens Q96IV0
Y2H Array
31515488
Intra
TRAFD1 O14545 NGLY1 Homo sapiens Q96IV0
Validated Y2H
25416956
Intra
TRAFD1 O14545 NGLY1 Homo sapiens Q96IV0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TRAFD1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83802 TRAFD1 Antibody (YA3499) WB, ICC/IF, FC, ELISA Human
HY-P83802A TRAFD1 Antibody (YA3499)(PBS only) WB, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Choroid Plexus Meningioma

  • Choroid Meningioma

  • Meningioma Of The Choroid Plexus
Central Nervous System Tuberculosis

  • Intracranial Tuberculoma

  • Tuberculoma Of Brain

  • Tuberculosis Of Meninges And Central Nervous System

  • Tuberculous Abscess Of Brain

  • Tuberculoma, Intracranial

  • Tuberculosis, Central Nervous System
Type 1 Diabetes Mellitus 3

  • Diabetes Mellitus, Insulin-Dependent, 3

  • Iddm3

  • Insulin-Dependent Diabetes Mellitus 3

  • T1D3
Noonan Syndrome 1

  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male
Type 1 Diabetes Mellitus 2

  • Diabetes Mellitus, Noninsulin-Dependent, 1

  • Diabetes Mellitus, Insulin-Dependent, 2

  • IDDM2

  • Insulin-Dependent Diabetes Mellitus 2

  • NIDDM1

  • Diabetes Mellitus, Noninsulin-Dependent 1

  • T1D2

  • Type 2 Diabetes Mellitus 1

  • T2D1

  • Noninsulin-Dependent Diabetes Mellitus 1

  • Diabetes Mellitus, Non-Insulin-Dependent, 1

  • Type 2 Diabetes Mellitus 1, Susceptibility To

  • Diabetes Mellitus, Insulin-Dependent, Type 2

  • Diabetes Mellitus, Non-Insulin-Dependent
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14977 TRAFD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRAFD1 RGD RGD:620171
Felis catus TRAFD1 VGNC VGNC:66503
Bos taurus TRAFD1 VGNC VGNC:97319
Macaca mulatta TRAFD1 VGNC VGNC:79459
Canis familiaris TRAFD1 VGNC VGNC:47771
Mus musculus TRAFD1 MGD MGI:1923551
Others TRAFD1 NCBI