1. Membrane Transporter/Ion Channel
  2. CFTR
  3. K41498 TFA

K41498 TFA 

Cat. No.: HY-P1106A
Handling Instructions

K41498 TFA is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF, CRF and CRF1 receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF- and hCRF-expressing cells. K41498 TFA can be used for hypotension study.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

K41498 TFA Chemical Structure

K41498 TFA Chemical Structure

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Description

K41498 TFA is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF, CRF and CRF1 receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF- and hCRF-expressing cells. K41498 TFA can be used for hypotension study[1].

Molecular Weight

3746.22

Formula

C₁₆₄H₂₇₇F₃N₄₈O₄₈

Sequence

{D-Phe}-His-Leu-Leu-Arg-Lys-{Nle}-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2

Sequence Shortening

{D-Phe}-HLLRK-{Nle}-IEIEKQEKEKQQAANNRLLLDTI-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

K41498K 41498K-41498CFTRCystic fibrosis transmembrane conductance regulatorCRF2 receptorhypotensionInhibitorinhibitorinhibit

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