HINT2 - histidine triad nucleotide binding protein 2 Gene

Also Known as HIT-17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84681

About HINT2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,812,960-35,815,479 (from NCBI)

This gene has 7 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 37.3), fat (RPKM 32.0) and 25 other tissues.

Summary

Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

HINT2 Products (1)

mRNA Protein Name
NM_032593.3 NP_115982.1 adenosine 5'-monophosphoramidase HINT2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenosine 5'-monophosphoramidase activity IDA
IDA: Inferred from direct assay
16762638 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
35156780 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
16762638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HINT2 Protein Structure

HIT

HIT: HIT domain (64 - 157)

  • 0
  • 100
  • 163 a.a.
Protein Preferred Names Protein Names

adenosine 5'-monophosphoramidase HINT2

  • HINT-2

HINT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HINT2 Q9BX68 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ocular Melanoma

  • Intraocular Melanoma

  • Uveal Melanoma

  • Eye Melanoma

  • Melanoma Of Eye

  • Melanoma Of The Uvea

  • Malignant Melanoma Of Eye
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06177 HINT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22554 Hint2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29074 Hint2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HINT2 VGNC VGNC:73411
Mus musculus HINT2 MGD MGI:1916167
Rattus norvegicus HINT2 RGD RGD:1308910
Canis familiaris HINT2 VGNC VGNC:49721
Felis catus HINT2 VGNC VGNC:62817
Bos taurus HINT2 VGNC VGNC:29855
Others HINT2 NCBI