SRP68 - signal recognition particle 68 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6730

About SRP68

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,038,785-76,072,517 (from NCBI)

This gene has 13 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 29.4), esophagus (RPKM 22.8) and 25 other tissues.

Summary

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

SRP68 Products (3)

mRNA	Protein	Name
NM_001260502.2	NP_001247431.1	signal recognition particle subunit SRP68 isoform 2
NM_001260503.2	NP_001247432.1	signal recognition particle subunit SRP68 isoform 3
NM_014230.4	NP_055045.2	signal recognition particle subunit SRP68 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables 7S RNA binding	IMP IMP: Inferred from mutant phenotype	27899666	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16672232	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	27899666	GOA
contributes to ribosome binding	IMP IMP: Inferred from mutant phenotype	27899666	GOA
enables signal recognition particle binding	IPI IPI: Inferred from physical interaction	17254600	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	18089836	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of signal recognition particle	IDA IDA: Inferred from direct assay	27899666	GOA
part of signal recognition particle, endoplasmic reticulum targeting	IDA IDA: Inferred from direct assay	18089836	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
signal recognition particle subunit SRP68	signal recognition particle 68 kDa protein

SRP68 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SRP68	Q9UHB9	SRP72	Homo sapiens	O76094	Anti Tag CoIP	33961781
Intra	SRP68	Q9UHB9	SRP72	Homo sapiens	O76094	Anti Tag CoIP	35271311
Intra	SRP68	Q9UHB9	SRP19	Homo sapiens	P09132	Anti Tag CoIP	35271311
Intra	SRP68	Q9UHB9	SRP19	Homo sapiens	P09132	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bladder Transitional Cell Papilloma	Bladder Papilloma Transitional Cell Papilloma Of Bladder Urinary Bladder Urothelial Papilloma Urothelial Papilloma Bladder Urothelial Papilloma
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Immunodeficiency 51	IMD51 Candf5 Candidiasis, Familial, 5 Candidiasis, Familial, 5, Formerly Candf5, Formerly Familial Candidiasis 5 Candidiasis Familial 5 Autosomal Recessive Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive Chronic Mucocutaneous Candidiasis 5
Bladder Papillary Transitional Cell Neoplasm	Urinary Bladder Papillary Urothelial Neoplasm Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm	Inverted Papilloma Of Urinary Tract Papillary Transitional Cell Neoplasm Of The Urinary Tract Urinary Tract Inverted Papilloma Inverted Urothelial Papilloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS13774	SRP68 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRP68	VGNC	VGNC:77883
Mus musculus	SRP68	MGD	MGI:1917447
Rattus norvegicus	SRP68	RGD	RGD:1305376
Felis catus	SRP68	VGNC	VGNC:65684
Bos taurus	SRP68	VGNC	VGNC:35286
Canis familiaris	SRP68	VGNC	VGNC:46808
Others	SRP68	NCBI