DSTN - destrin, actin depolymerizing factor Gene

Homo sapiens

Also known as ADF; ACTDP; HEL32; bA462D18.2

Gene ID: 11034 | Gene type: protein coding

About DSTN

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:17,570,075-17,609,919 (from NCBI)

This gene has 3 transcripts (splice variants), 127 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 293.6), esophagus (RPKM 273.4) and 25 other tissues.

Summary

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

DSTN Products(2)

mRNA	Protein	Name
NM_001011546.2	NP_001011546.1	destrin isoform b
NM_006870.4	NP_006861.1	destrin isoform a

DSTN Protein Structure

Cofilin_ADF

0
100
165 a.a.

Protein Preferred Names

Protein Names

destrin

actin-depolymerizing factor

Related Diseases

Diseases

Alias

Conjugate Gaze Palsy

Palsy Of Conjugate Gaze	Supranuclear Ocular Palsy
Gaze Palsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04029	DSTN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DSTN	VGNC	VGNC:40111
Mus musculus	DSTN	MGD	MGI:1929270
Macaca mulatta	DSTN	VGNC	VGNC:71841
Bos taurus	DSTN	VGNC	VGNC:28226
Felis catus	DSTN	VGNC	VGNC:80087
Rattus norvegicus	DSTN	RGD	RGD:1588366