2. Membrane Transporter/Ion Channel
  3. CFTR
  4. GlyH-101

GlyH-101 

Cat. No.: HY-18336 Purity: 98.24%
COA Handling Instructions

GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current.

For research use only. We do not sell to patients.

GlyH-101 Chemical Structure

GlyH-101 Chemical Structure

CAS No. : 328541-79-3

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Solution
10 mM * 1 mL in DMSO USD 106 In-stock
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10 mM * 1 mL
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10 mg USD 150 In-stock
50 mg USD 624 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    GlyH-101 purchased from MCE. Usage Cited in: Sci Rep. 2018 Apr 16;8(1):6028.  [Abstract]

    Western blot analysis of expression and phosphorylation of H3 in GlyH-101 (10 nM for 48 hours)-treated cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current[1][2].

    In Vitro

    GlyH-101 (0-50 µM) shows antiproliferative activity in PCT and PS120 cells[1].
    GlyH-101 (0.5, 1, 5, 10 µM) inhibits CFTR-like current in a concentration-dependent manner in PCT cells[1].
    GlyH-101 (0.5, 1, 5, 10 µM) inhibits the VSORC current with IC50s of 5.38, 6.26 µM for PS120, PCT cells, respectively[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: PCT, PS120 cells
    Concentration: 0, 1, 5, 10, 20, 50 µM
    Incubation Time: 24 h
    Result: Inhibited the cell growth in a dose-dependent manner.
    In Vivo

    GlyH-101 (2.5 µg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    493.15

    Appearance

    Solid

    Formula

    C19H15Br2N3O3
    CAS No.
    SMILES

    O=C(N/N=C/C1=CC(Br)=C(O)C(Br)=C1O)CNC2=CC3=CC=CC=C3C=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 58 mg/mL (117.61 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0278 mL 10.1389 mL 20.2778 mL
    5 mM 0.4056 mL 2.0278 mL 4.0556 mL
    10 mM 0.2028 mL 1.0139 mL 2.0278 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.07 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    • If you have published this work, please enter the PubMed ID.
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    GlyH-101328541-79-3GlyH101GlyH 101CFTRCystic fibrosis transmembrane conductance regulatorantiproliferativePCTPS120 cellsVSORCCFTR-like currentintestinal fluidInhibitorinhibitorinhibit

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